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EC number: 211-322-8 | CAS number: 638-16-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Acute toxicity after oral exposure in female rats: cut-off LD50 value of 500 mg/kg bw (calculated: LD50 = 1150 mg/kg bw)
Acute toxictiy after oral exposure in mice: LD50 = 2280 mg/kg bw (male), LD50 = 2500 mg/kg bw (female)
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- Deviations:
- no
- GLP compliance:
- not specified
- Test type:
- acute toxic class method
- Limit test:
- no
- Species:
- rat
- Strain:
- other: Sprague-Dawley (Crl; CD (SD), SPF
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 7 weeks at study initiation / 8 weeks at test item administration
- Weight at study initiation: 9 females 258.4 - 183.6 g
- Fasting period before study: 16 hours
- Housing: individually
- Diet: ad libitum
- Water: ad libitum
- Acclimation period: 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 23.0 - 24.5° C
- Humidity (%): 49 - 59%
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 24.05.2005 To: 14.06.2005 - Route of administration:
- oral: gavage
- Vehicle:
- other: 0.5% carboxymethyl cellulose sodium solution
- Doses:
- 300 mg/kg and 2000 mg/kg
- No. of animals per sex per dose:
- 3
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 15 days (administration day was taken as observation day 1)
- Frequency of observations: First and second stage (300 mg/kg) 30 min, 60 min, 2 h, 3 h, 4 h, 5 h, 6 h and once daily thereafter; third stage (2000 mg/kg) 30 min, 60 min, 90 min, 120 min, 150 min, 180 min, 4 h, 5 h, 6 h and once daily thereafter
- Frequency of weighing: First and second stage (300 mg/kg): day 1 (dosage administration day), day 2, day 4, day 8, day 11 and day 15
Third stage (2000 mg/kg): day 1 (before administration), day 2, day 3, day 4
- Necropsy of survivors performed: yes
- Other examinations performed: gross examination of organs at necropsy, organ weights, histopathology - Key result
- Sex:
- female
- Dose descriptor:
- LD50 cut-off
- Effect level:
- 500 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: according to OECD 423
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 1 150 mg/kg bw
- Based on:
- test mat.
- Mortality:
- 300 mg/kg bw (stage 1): 0/3
300 mg/kg bw (stage 2): 0/3
2000 mg/kg bw (stage 3): 3/3
At 2000 mg/kg bw mortalities occurred in 1 case after about 2 hours after dosage, the 2 remaining test animals died on the third and fourth observation day.
No mortality occurred following a single oral administration of 300 mg/kg bw trithiocyanuric acid. - Clinical signs:
- other: No toxicity was displayed in rat with a single oral administration of 300 mg/kg trithiocyanuric acid, but with 2000 mg/kg bw administration clearly lead to the death of the animal system.
- Gross pathology:
- Full body rigor was identified immediately after death in the one animal that died within about 2 hours after administering 2000 mg/kg bw. Contamination of perirhinal hair, enlargement of kidney, spleen and adrenal gland, and downsizing of pancreas were identified in the 2 animals that died on the 3rd and 4th observation day, and a dark red region in the lung was identified in the animal that died on the 3rd observation day. The stomach revealed whitish liquid residues in the animals, that died on the administration day and on the 3rd observation day after administration of 2000 mg/kg bw. Furthermore, the right atrium was filled with blood in all 3 rats, that died.
No abnormal findings were noted in animals dosed with 300 mg/kg bw. - Other findings:
- Histopathology:
Histopathology was restricted to animals administered 2000 mg/kg bw.
Proximal tubular epithelium cortical substance degeneration/necrosis as well as cortical glumerular degeneration/necrosis and edema in the papilla region was identified in all three animals. In the rats, which died on the 3rd and 4th observation day, medullary collecting duct epithelium degeneration/necrosis, necrosis of the papilla and cell infiltration in blood vessels was observed and was also seen in the hyaline droplets in the glomerular of the papillary region. In addition, mineral deposits in the cortical layer and hyaline cylinder in the medulla were identified in these two animals. In the animal that died on the 3rd observation day the cortical distale tubule lumen was extended.
Very slight to slight extramedullary haemopoeisis and lipofuscin sediment in all animals were noted in the pancreas. A clear reduction of the spleen white pulp region was identified in the rats, that died on the 3rd and 4th observation day.
Congestion was observed in all animals' lung.
In the lung, edema and aggregation of foamy cells in alveoli were noted in the animals, that died on the 3rd and 4th observation day. In addition, the animal that died on the 3rd observation day infiltration of neutrophilic leukocytes in the alveolar septa was found.
Periportal fat in liver cells and vascular degeneration of liver cells in lobules were seen in all three animals.
No histopathological findings were observed in heart, brain and stomach. - Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- In this acute oral toxicity study in the female rat a cut-off LD50 value of 500 mg/kg bw was found. In addition the LD50 was calculated to be 1150 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 1 150 mg/kg bw
- Quality of whole database:
- Guideline study according to OECD TG available (reliable without restrictions).
Acute toxicity: via inhalation route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Acute toxicity: via dermal route
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
Based on the LD50 cut-off (rat) = 500 mg/kg bw, the test substance Taicros TMT is classified as Acute Tox. Cat. 4 (oral) according to CLP Regulation (EC) No.1272/2008.
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