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EC number: 208-307-3 | CAS number: 521-18-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No repeated dose studies are available with androstenolone. However some study results are cited in RTECS database (Jan 2010):
Dermal, 28 days (Hamster): TDLo: 0.112 mg/kg/28D-I
[Biological and pharmaceutical bulletin. (Pharmaceutical Society of Japan, 2-12-15, Shibuya, Shibuya-ku, Tokyo 150-0002, Japan) V.1- 1993- v. 25, p. 622, 2002 (BIPBU*)]
Subcutaneous, 10 weeks (Rat): TDLo: 35 mg/kg/10W-I
[European Journal of Cancer (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V. 1- 1965- v. 37, p. 443, 2001 (EJCAAH)]
Subcutaneous, 32 days (Quail): TDLo: 320 mg/kg/32D-I
[Hormones and Behavior. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- v. 49, p. 4, 2006 (HOBEAO)]
Intramuscular, 33 days (domestic animal: sheep, goat): TDLo: 240 ug/kg/4D-I
[Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- v. 123, p. 527, 2002 (JRPFA4)]
Subcutaneous, 15 days (Rat): TDLo: 75 mg/kg/15D-I
[Pharmacology, Biochemistry and Behavior. (ANKHO International Inc., P.O. Box 426, Fayetteville, NY 13066) V.1- 1973- v. 89, p. 241, 2008 (PBBHAU)]
Subcutaneous, 3 days (Rat): TDLo: 600 mg/kg/3D-I
[Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- v. 170, p. 21, 2002 (TXCYAC).]
Oral, 10 days (Rat): TDLo: 400 mg/kg/10D-I
[Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- v. 195, p. 177, 2004 (TXCYAC)]
Key value for chemical safety assessment
Additional information
There are no repeated dose studies available with androstenolone. However some study results are cited in RTECS database (Jan 2010):
The daily dermal application of adrostanolone to hamsters over 28 days results in androgenic effects not further specified; TDLo: 0.112 mg/kg/28D-I [Biological and pharmaceutical bulletin. (Pharmaceutical Society of Japan, 2-12-15, Shibuya, Shibuya-ku, Tokyo 150-0002, Japan) V.1- 1993- v. 25, p. 622, 2002 (BIPBU*)]
The daily subcutaneous application of androstanolone over 10 weeks to rat protects against induction of experimental tumors; TDLo: 35 mg/kg/10W-I [European Journal of Cancer (Elsevier Science, P.O.Box 7247-7682,Philadelphia,PA 19170 -7682,USA OR Elsevier Science B.V.,P.O.Box 1270,1000 BG Amsterdam,The Netherlands) V. 1- 1965- v. 37, p. 443, 2001 (EJCAAH)]
Androstanolone daily applied subcutaneously to quails over 32 days results in aggressiv behaviour and changes in testicular weight; TDLo: 320 mg/kg/32D-I [Hormones and Behavior. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1969- v. 49, p. 4, 2006 (HOBEAO)]
The daily intramuscular application of androstanolone to domestic animals (sheep, goat) over 33 days leads to changes in gonadotropins on menstrual cycle; TDLo: 240 ug/kg/4D-I [Journal of Reproduction and Fertility. (Biochemical Soc. Book Depot, POB 32, Commerce Way, Colchester, Essex CO2 8HP, UK) V.1- 1960- v. 123, p. 527, 2002 (JRPFA4)]
Androstanolone applied daily subcutaneously over a period of 15 days to rats leads to a paternal effects on male not further specified; TDLo: 75 mg/kg/15D-I [Pharmacology, Biochemistry and Behavior. (ANKHO International Inc., P.O. Box 426, Fayetteville, NY 13066) V.1- 1973- v. 89, p. 241, 2008 (PBBHAU)]
The daily subcutaneous application over 3 days to rats results in maternal effects on uterus, cervix and vagina; TDLo: 600 mg/kg/3D-I [Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- v. 170, p. 21, 2002 (TXCYAC).]
Oral application over 10 days to rats leads to effects on prostate, seminal vessicle, Cowper's gland and accessory glands; TDLo: 400 mg/kg/10D-I [Toxicology. (Elsevier Scientific Pub. Ireland, Ltd., POB 85, Limerick, Ireland) V.1- 1973- v. 195, p. 177, 2004 (TXCYAC)]
Justification for classification or non-classification
There is no classification required according to Directive 67/548/EEC and Regulation (EC) 1272/2008 (CLP).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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