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EC number: 206-076-3 | CAS number: 299-29-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
Link to relevant study record(s)
- Endpoint:
- activated sludge respiration inhibition testing
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 209 (Activated Sludge, Respiration Inhibition Test
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Analytical monitoring:
- no
- Vehicle:
- no
- Details on test solutions:
- GDL was diluted with demineralised water to obtain the desired concentrations.
- Test organisms (species):
- activated sludge
- Details on inoculum:
- Activated sludge of Rouen treatment plant system was taken the day of the essay (March 25th, 2010 for preliminary test and March 30th, 2010 for definitive test).
Activated sludge was washed twice with dechlorinated water and put back in suspension to obtain a concentration approximately 4 g/L (4.111 g/L for preliminary test and 3.944 g/L for definitive test).
This value gives a concentration approximately 1.6 g/L in the final volume. - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 3 h
- Test temperature:
- 20°C ± 2°C
- Nominal and measured concentrations:
- For definitive test theoretical concentration = 100.03625, 200.0725, 400.145, 800.29, 1600.58 mg/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: flasks of 660mL
- No. of vessels per concentration (replicates): one per concentration
- No. of vessels per control (replicates): two vessels
TEST MEDIUM
Peptone (16.01699 g), beef extract (11.01693 g), urea (3.00898 g), Sodium chloride NaCl (0.70318 g), Calcium chloride CaCl2, 2H2O (0.40622 g), Magnesium sulphate MgSO4, 7H2O (0.20994 g), and DiPotassium hydrogenophosphate, KH2PO4 (2.79980 g) dissolved in demineralised water and completed to 1L.
EFFECT PARAMETERS MEASURED: After 3 hours of incubation, measured the respiration rate in each flask with an oxymeter during a maximum time of 12 minutes.
TEST CONCENTRATIONS
- Range finding study Test concentrations: 1.00039, 10.0039, 100.039, 1000.39, 10003.9 mg/L
- Range finding study Results used to determine the conditions for the definitive study: Yes - Reference substance (positive control):
- yes
- Remarks:
- 3,5-Dichlorophenol
- Duration:
- 3 h
- Dose descriptor:
- EC50
- Effect conc.:
- 649.8 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Remarks on result:
- other: Confidence limits at 95% 321.1 – 978.5 mg/L
- Duration:
- 3 h
- Dose descriptor:
- NOEC
- Effect conc.:
- 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- inhibition of total respiration
- Remarks:
- respiration rate
- Results with reference substance (positive control):
- EC50 of 3,5-Dichlorophenol was between 5 and 30 mg/l (9.6 mg/l for definitive test).
- Reported statistics and error estimates:
- EC50 (Effect Concentration) and confidence limits were obtained by calculation according to linear regression (Probits).
- Validity criteria fulfilled:
- yes
- Conclusions:
- Via read across Iron Gluconate is classified as non-hazardous for this end point
- Executive summary:
Via read across Iron Gluconate is classified as non-hazardous for this end point
Reference
Via read across Iron Gluconate is classified as non-hazardous for this end point
Description of key information
There are no toxicity to microorganisms studies on ferrous gluconate. Results of a study conducted with a structurally similar compoud, D-glucono-1,5-lactone , are reported and used for read across.
Via read across Iron Gluconate is classified as non-hazardous for this end point
Key value for chemical safety assessment
- EC50 for microorganisms:
- 649.8 mg/L
- EC10 or NOEC for microorganisms:
- 100 mg/L
Additional information
Via read across Iron Gluconate is classified as non-hazardous for this end point
Iron Gluconate does not have any of the key properties that would alert for toxicity to microorganisms. The lack of an alert and the physical-chemical properties indicate that iron gluconate should not be toxic to microorganisms.
Removal of Iron Gluconate by means of activated sludge would be via a similar mechanism as for D-glucono-1,5-lactone; the biodegradation of the gluconate ion, not adsorption to sludge or volatilization. The LC50 figure for D-glucono-1,5-lactone is 650 mg/L. However, the confidence limits at 95% are between 321 – 979 mg/L. Iron Gluconate can be read across to D-glucono-1,5-lactone due to the comparable structures and relevant properties.
Full read across justification summary is attached to the end point summary
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