Metam-sodium

Toxicity to microorganisms

Link to relevant study record(s)

Reference

Endpoint:

toxicity to microorganisms, other

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

4 (not assignable)

Rationale for reliability incl. deficiencies:

secondary literature

Justification for type of information:

Data is from IUCLID dataset

Qualifier:

according to guideline

Guideline:

other: as mention below

Principles of method if other than guideline:

Pseudomonas cell proliferation inhibition test by the chemical metam-sodium for 18 hrs was carried out.

GLP compliance:

not specified

Specific details on test material used for the study:

- Name of test material : Metam-sodium
- Molecular formula : C2H4NNaS2
- Molecular weight : 129.1826 g/mol
- Smiles notation : C(=S)(NC)[S-].[Na+]
- InChl : 1S/C2H5NS2.Na/c1-3-2(4)5;/h1H3,(H2,3,4,5);/q;+1/p-1
- Substance type: Organic
- Physical state: Solid

- Chemical source: UCB–Chemicals Gent

Analytical monitoring:

not specified

Vehicle:

not specified

Test organisms (species):

Pseudomonas putida

Test type:

not specified

Water media type:

freshwater

Total exposure duration:

18 h

Reference substance (positive control):

not specified

Key result

Duration:

18 h

Dose descriptor:

EC10

Effect conc.:

0.6 mg/L

Nominal / measured:

nominal

Conc. based on:

test mat.

Basis for effect:

other: cell proliferation inhibition

Remarks on result:

other: Other details not known

Validity criteria fulfilled:

not specified

Conclusions:

After the 18 hrs exposure of chemical with the test organism, the EC10 was observed at 0.6 mg/l.

Executive summary:

Pseudomonas cell proliferation inhibition test by the chemical metam-sodium for 18 hrs was carried out. After the 18 hrs exposure of chemical with the test organism, the EC10 was observed at 0.6 mg/l. Thus chemical was consider as toxic to the growth of microorganism Pseudomonas putida.

Description of key information

Pseudomonas cell proliferation inhibition test by the chemical metam-sodium for 18 hrs was carried out. After the 18 hrs exposure of chemical with the test organism, the EC10 was observed at 0.6 mg/l. Thus chemical was consider as toxic to the growth of microorganism Pseudomonas putida.

Key value for chemical safety assessment

EC10 or NOEC for microorganisms:

0.6 mg/L

Additional information

Based on the various experimental data for the target chemical Metam-sodium (137-42-8) study have been reviewed to determine toxic nature of on the growth and other activity of invertebrates. The studies are as mentioned below: 

 

In the first study for the target chemical Metam-sodium (137-42-8) from (IUCLID dataset 2000) toxicity was measure on the growth of microorganisms. Pseudomonas cell proliferation inhibition test by the chemical metam-sodium for 18 hrs was carried out. After the 18 hrs exposure of chemical with the test organism, the EC10 was observed at 0.6 mg/l. Thus chemical was consider as toxic to the growth of microorganism Pseudomonas putida.

 

Similarly in the second study for the target chemical Metam-sodium (137-42-8) from (IUCLID dataset 2000) determine the nature of chemical on the microorganisms. Aim of this study was to determine the toxic effect of chemical on the Short-term breathing of activated sludge (aquatic bacteria). After the exposure of chemical metam-sodium with the test organism activated sludge, the EC20 was observed at > 1995 mg/l. Thus chemical was consider as nontoxic to the growth of microorganism Pseudomonas putida.