Registration Dossier
Registration Dossier
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EC number: 236-610-0 | CAS number: 13450-90-3
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 002
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- JAPAN: Guidelines for Screening Mutagenicity Testing Of Chemicals
- Version / remarks:
- umu test
- GLP compliance:
- not specified
- Type of assay:
- SOS/umu assay
Test material
- Reference substance name:
- Gallium trichloride
- EC Number:
- 236-610-0
- EC Name:
- Gallium trichloride
- Cas Number:
- 13450-90-3
- Molecular formula:
- Cl3Ga
- IUPAC Name:
- gallium trichloride
- Test material form:
- not specified
Constituent 1
- Specific details on test material used for the study:
- purity > 99.9%
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 1535
- Metabolic activation:
- with and without
- Metabolic activation system:
- S-9 mix: a mixture of the microsome fraction of a rat liver with coenzymes such as reduced nicotinamide adenine dinucleotide phosphate and reduced nicotinamide adenine dinucleotide, was used
- Test concentrations with justification for top dose:
- at least 6 concentrations, ranging from 7.2 × 10−7 to 1.4 × 10−4 mol/L
- Vehicle / solvent:
- In advance of mutagenic evaluation, each of the salts was dissolved in and diluted with sterile Dulbecco’s phosphate- buffered saline without calcium and magnesium salts [PBS(−)] to prepare a proper metal salt solution, which would provide a desired final concentration of the salt in the medium.
Controls
- Untreated negative controls:
- yes
- Remarks:
- PBS
- Positive controls:
- yes
- Positive control substance:
- furylfuramide
- other: 2-aminoanthracene
Results and discussion
Test results
- Key result
- Species / strain:
- S. typhimurium TA 1535
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- no cytotoxicity
Applicant's summary and conclusion
- Conclusions:
- The test item Gallium trichloride is not mutagenic, with or without metabolic activation (S9 mix).
- Executive summary:
The test item Gallium trichloride is not mutagenic, with or without metabolic activation (S9 mix).
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