Registration Dossier
Registration Dossier
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EC number: 203-273-6 | CAS number: 105-13-5
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Justification for type of information:
- Data is from Publication.
Data source
Referenceopen allclose all
- Reference Type:
- publication
- Title:
- A toxicological assessment of aryl alkyl alcohol
- Author:
- Belsito et al.
- Year:
- 2 012
- Bibliographic source:
- Food and Chemical Toxicology
- Reference Type:
- publication
- Title:
- Fragrance material review
- Author:
- Scognamiglio et al.
- Year:
- 2 012
- Bibliographic source:
- Food and Chemical Toxicology
- Reference Type:
- other: Peer reviewed journal
- Title:
- Fragrance raw materials monographs
- Author:
- D. L. J. Opdyke
- Year:
- 1 974
- Bibliographic source:
- Food and Cosmetics Toxicology
- Reference Type:
- other: authoritative database
- Title:
- Acute Dermal toxicity - Test chemical
- Author:
- U.S. National Library of Medicine
- Year:
- 2 018
- Bibliographic source:
- ChemIDplus
- Reference Type:
- other: Authoritative database
- Title:
- Toxicity of test chemical
- Author:
- IFA GESTIS
- Year:
- 2 018
- Bibliographic source:
- GESTIS Substance Database
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- Acute dermal toxicity study of the given test chemical was performed in rabbit.
- GLP compliance:
- not specified
- Test type:
- other: not specified
- Limit test:
- no
Test material
- Reference substance name:
- 4-methoxybenzyl alcohol
- EC Number:
- 203-273-6
- EC Name:
- 4-methoxybenzyl alcohol
- Cas Number:
- 105-13-5
- Molecular formula:
- C8-H10-O2
- IUPAC Name:
- (4-methoxyphenyl)methanol
- Details on test material:
- - IUPAC Name: 4-methoxybenzyl alcohol
- Common Name: Anisyl alcohol
- InChI: 1S/C8H10O2/c1-10-8-4-2-7(6-9)3-5-8/h2-5,9H,6H2,1H3
- Smiles: c1(ccc(OC)cc1)CO
- Molecular formula :C8H10O2
- Molecular weight :138.165 g/mole
- Substance type:organic
- Physical state:Liquid, colorless to yellowish fruity odour.
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
- Sex:
- not specified
- Details on test animals or test system and environmental conditions:
- not specified
Administration / exposure
- Type of coverage:
- other: Dermal
- Vehicle:
- not specified
- Details on dermal exposure:
- not specified
- Duration of exposure:
- not specified
- Doses:
- 1.25, 2.5, and 5.0 g/kg.
- No. of animals per sex per dose:
- Groups of four rabbits
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 6 days
- Frequency of observations and weighing: Animals were observed for mortality and clinical signs. - Statistics:
- not specified
Results and discussion
- Preliminary study:
- not specified
Effect levels
- Sex:
- not specified
- Dose descriptor:
- LD50
- Effect level:
- 3 000 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- 1 940 - 4 060
- Mortality:
- Mortalities included one rabbit from the 2.5 g/kg group on day 1, and all four rabbits from the 5.0 g/kg group by day 6.
- Clinical signs:
- other: Clinical signs of toxicity included loss of coordination and muscle tone in two animals at 5.0 g/kg and one animal at 2.5 g/kg. Slight to moderate erythema and edema was also observed in all animals.
- Gross pathology:
- not specified
- Other findings:
- not specified
Applicant's summary and conclusion
- Interpretation of results:
- other: Not classified
- Conclusions:
- Acute dermal toxicity dose (LD50) value was considered to be 3.0 g/kg, with 95% confidence limits of 1.94–4.06 g/kg, when Groups of four rabbits were treated with the given test chemical by dermal application.
- Executive summary:
Acute dermal toxicity study was conducted by using the given test chemical in Groups of four rabbits at the dose concentration of 1.25, 2.5, and 5.0 g/kg. Animals were observed for mortality and clinical signs for 6 days.
Mortalities included one rabbit from the 2.5 g/kg group on day 1, and all four rabbits from the 5.0 g/kg group by day 6. Clinical signs of toxicity included loss of coordination and muscle tone in two animals at 5.0 g/kg and one animal at 2.5 g/kg. Slight to moderate erythema and edema was also observed in all animals.
Hence, the LD50 value was considered to be 3.0 g/kg, with 95% confidence limits of 1.94–4.06 g/kg, when Groups of four rabbits were treated with the given test chemical by dermal application.
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