Registration Dossier
Registration Dossier
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EC number: 204-493-5 | CAS number: 121-69-7
Repeated dose toxicity: inhalation
Administrative data
- Endpoint:
- repeated dose toxicity: inhalation
- Remarks:
- other: Subchronic/chronic toxicity
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- CESARS Record no.:209
- Author:
- Markosyan, T.M.
- Year:
- 2 011
- Bibliographic source:
- CESARS (Chemical Evaluation Search and Retrieval System ); Markosyan, T.M. 1969. Comparative toxicity of monomethyl-aniline and dimethyl-aniline in chronic experimental exposure. Gig. Sanit.34(3)7-11. (Russ.). From CAS:71:11369.
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Study obtained from CESARS
- GLP compliance:
- not specified
Test material
- Reference substance name:
- N,N-dimethylaniline
- EC Number:
- 204-493-5
- EC Name:
- N,N-dimethylaniline
- Cas Number:
- 121-69-7
- Molecular formula:
- C8H11N
- IUPAC Name:
- N,N-dimethylaniline
- Details on test material:
- - Name of test material (as cited in study report): N,N-dimethylaniline
- Substance type: Organic
- Physical state: liquid
Constituent 1
Test animals
- Species:
- rat
- Strain:
- not specified
- Sex:
- not specified
Administration / exposure
- Route of administration:
- inhalation
- Type of inhalation exposure:
- not specified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 24 hr/day for 100 days
Results and discussion
Effect levels
- Dose descriptor:
- LOAEC
- Effect level:
- 0.3 mg/m³ air
- Based on:
- test mat.
- Sex:
- not specified
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- Rats inhaling 0.3 mg/m3 N,N-dimethylaniline on this dosage schedule showed significant changes in the central nervous system, blood and liver in the correlation of muscle antagonist chronaxy, a reduced number of erythrocytes and hemaglobin, increased methemoglobin level, reticulocytis, leukopenia, hypoproteinemia, a reduced-SH group content in the serum, and accumulation of pyruvic acid in the liver and serum. Dimethylaniline also increased the coproporphyrin urinary excretion and reduced the adrenal ascorbic acid level.
- Executive summary:
Rats inhaling 0.3 mg/m3 N,N-dimethylaniline on this dosage schedule showed significant changes in the central nervous system, blood and liver in the correlation of muscle antagonist chronaxy, a reduced number of erythrocytes and hemaglobin, increased methemoglobin level, reticulocytis, leukopenia, hypoproteinemia, a reduced-SH group content in the serum, and accumulation of pyruvic acid in the liver and serum. Dimethylaniline also increased the coproporphyrin urinary excretion and reduced the adrenal ascorbic acid level.
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