Potassium dichromate

Genetic toxicity: in vitro

Administrative data

Endpoint:

genetic toxicity in vitro

Remarks:

Type of genotoxicity: other: Various in vitro methods are reviewed

Type of information:

migrated information: read-across based on grouping of substances (category approach)

Adequacy of study:

weight of evidence

Study period:

Not applicable

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

The EU RAR summarises a very large number of genotoxicity studies of varying quality and largely performed to non-standard designs. However the consistently positive responses mean that the studies taken as a whole are reliable. The RAR also covers studies discussed in earlier reviews by the UK HSE (1989) and the UK IOH (1997).

Data source

Reference

Reference Type:

other: EU RAR

Title:

European Union Risk Assessment Report: chromium trioxide, sodium chromate, sodium dichromate, ammonium dichromate, potassium dichromate

Author:

European Chemicals Bureau

Year:

2005

Bibliographic source:

3rd Priority List; Volume 53

Materials and methods

Test guideline

Qualifier:

no guideline followed

Deviations:

not applicable

Principles of method if other than guideline:

The EU RAR summarises the results of a large number of studies in vitro performed using chromium (VI) compounds, to various (and largely non-standard) protocols.

GLP compliance:

not specified

Remarks:

Mainly published studies

Type of assay:

other: Various in vitro methods are reviewed

Test material

Test material information

Constituent 1

Reference substance name:

Chromium trioxide

EC Number:

215-607-8

EC Name:

Chromium trioxide

Cas Number:

1333-82-0

IUPAC Name:

1333-82-0

Constituent 2

Reference substance name:

Sodium chromate

EC Number:

231-889-5

EC Name:

Sodium chromate

Cas Number:

7775-11-3

IUPAC Name:

disodium dioxido(dioxo)chromium

Constituent 3

Reference substance name:

Sodium dichromate

EC Number:

234-190-3

EC Name:

Sodium dichromate

Cas Number:

10588-01-9

Constituent 4

Reference substance name:

Potassium dichromate

EC Number:

231-906-6

EC Name:

Potassium dichromate

Cas Number:

7778-50-9

Molecular formula:

K2Cr2O7

IUPAC Name:

sodium dichromate

Details on test material:

No further details

Method

Target gene:

Various

Test concentrations with justification for top dose:

Various

Results and discussion

Any other information on results incl. tables

The results of a very large number of studies performed in vitro with the water-soluble hexavlent chromium compounds are largely positive.

The EU RAR therefore concludes that there is a very large body of evidence indicating that the Cr (VI) ion in solution is directly mutagenic in in vitro systems; this conclusion is relevant to all compounds in this group.

Applicant's summary and conclusion

Conclusions:

Interpretation of results (migrated information):
positive weight of evidence approach

The weight of evidence in various test systems indicates that water soluble Cr (VI) compounds in this group are genotoxic in vitro.

Executive summary:

The EU RAR summarises the results of a number of in vitro studies of various designs and reliability performed over a number of years. The RAR itself also takes into account the findings of the earlier reviews of the toxicity of Cr (VI) compounds by the UK Health & Safety Executive (HSE, 1989) and the UK Institute of Health (IOH, 1997), which came to similar conclusions. It is concluded that water soluble Cr (VI) compounds are genotoxic in vitro.