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Diss Factsheets
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EC number: 206-466-3 | CAS number: 345-92-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2005-11-11 - 2005-12-30
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Guideline comparable study; restriction: no controls
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 006
- Report date:
- 2005
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- GLP compliance:
- yes
Test material
- Reference substance name:
- Bis(4-fluorophenyl) ketone
- EC Number:
- 206-466-3
- EC Name:
- Bis(4-fluorophenyl) ketone
- Cas Number:
- 345-92-6
- Molecular formula:
- C13H8F2O
- IUPAC Name:
- bis(4-fluorophenyl)methanone
- Reference substance name:
- 4,4'-Difluorobenzophenone
- IUPAC Name:
- 4,4'-Difluorobenzophenone
- Details on test material:
- bis(4-fluorophenyl) ketone,
purity: 99 %,
physical state: white powder,
storage conditions: test substance was stored in the refrigator of sample room and kept only in the original container
Constituent 1
Constituent 2
Test animals
- Species:
- rabbit
- Strain:
- other: Japanese White
- Details on test animals or test system and environmental conditions:
- TEST ORGANISMS:
- Source: Qianmin Animals Raising Farm of Yuhong District, Shenyang
- Strain: Adult Japanese White rabbits
- Weight at study initiation: 1.8 - 2.2 kg
- Diet: ad libitum
- Water: ad libitum
- Temperature (°C): 20 °C +/- 2° C
- Humidity (%): 55 % +/- 10 %
- Illumination: natural lights
- Number of animals: 2 males and 2 females
- Housing: each in individual cage (32x32x50 cm); cages and feeders were changed and sanitized weekly
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- other: soybean oil
- Controls:
- no
- Amount / concentration applied:
- 0.5 g (substance mixed with little soybean oil) per rabbit
- Duration of treatment / exposure:
- 4 hours
- Observation period:
- - Post dose observation period: 14 days
- Number of animals:
- 2 males and 2 females
- Details on study design:
- - Dose preparation and administration:
One day prior to being dosed, 4 healthy rabbits were selected for the study. At least 24 hours prior to application of the test substance, two areas (3x 3 cm2 each) on the back of each animal were shaved by using an electric clipper. Then the test substance mixed with a little soybean oil was applied (0.5 g per rabbit) to four layers of gauze (2.5 x 2.5 cm2) and smeared evenly, and then put to the shaved site on the left. The gauche patch was covered with one layer of plastic film and fixed with adhesive tape tightly to the animal. The animals were returned to their cages for observations. After four hours, the covering were removed and the application sites were rinsed completely with warm water.
- Observation and clinical signs:
Skin irritation was evaluated at 1 hr, and 1, 2, 3, 4, 7, and 14 days after test material application. The degree of irritation was scored. Animals were observed daily for mortality and signs of morbidity.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: 4 hrs, 24 hrs, 48 hrs, 72 hrs
- Score:
- 0
- Max. score:
- 8
- Remarks on result:
- other: None of the animals showed any signs of erythema or edema.
- Irritation parameter:
- erythema score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hrs
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Basis:
- mean
- Time point:
- other: 24, 48, 72 hrs
- Score:
- 0
- Max. score:
- 4
- Irritant / corrosive response data:
- AVERAGE SCORE
- Erythema: 0
- Edema: 0
REVERSIBILITY: not applicable - Other effects:
- Under the described test conditions none of the two male and two female rabbits showed any test substance related changes.
Any other information on results incl. tables
no further information
Applicant's summary and conclusion
- Interpretation of results:
- not irritating
- Remarks:
- Migrated information Criteria used for interpretation of results: OECD GHS
- Conclusions:
- Under the present test conditions, none of the two male and two female rabbits exposed for 4 hours to 0.5 g bis(4-fluorophenyl) ketone per patch and animal (okklusive) showed any test item-related changes at the examination time-points 4 hours, 24, 48 and 72 hours after patch removal. Therefore, bis(4-fluorophenyl) ketone is not irritating to skin.
- Executive summary:
The acute skin irritation properties of bis(4-fluorophenyl) ketone were estimated similar to OECD Guideline 404. A dose of 500 mg test item (in soybean oil) per animal was applied to the shaved, intact dorsal skin of 2 male and 2 female rabbits under occlusive conditions. After the 4 -hour exposure period the patch was removed and the resulting reactions were examined. The average scores at 4 hours, 24, 48 and 72 hours after patch removal are as follows: erythema/eschar: 0, edema: 0. Therefore, bis(4-fluorophenyl) ketone
is not irritating to skin.
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