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Diss Factsheets
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EC number: 203-894-2 | CAS number: 111-67-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Sediment toxicity
Administrative data
Link to relevant study record(s)
- Endpoint:
- sediment toxicity: short-term
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Study period:
- 14 August to 8 December 1995
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: GLP, guideline, available as unpublished report, notable limitations in reporting
- Justification for type of information:
- Read-across between the target substance Oct-2-ene (EC 203-894-2 / CAS 111-67-1) and source substance 1-Tetradecene (EC 214-306-9/ CAS 1120-36-1) is based upon the similarity of the chemical structures and their respective physico-chemical properties. The ECHA Read-Across Assessment Framework (RAAF) states that substances with qualitatively similar properties can form the basis of read-across in circumstances where the source and target substances share such similar characteristics.
Target substance Oct-2-ene and source substance 1-Tetradecene are each mono-constituent linear olefins. Structurally, the differences between source and target substances include: 1) the length of the carbon chain (eight for the target substance, and fourteen for the source substance); and 2) the location of the carbon-carbon double bond (uniformly at the C2 position for the target substance, but uniformly at the C1 terminal position for the source substance).
The target and source substances both fit within the boundaries of chemical category of higher olefins. Studies conducted by the HOPA consortium on a large range of higher olefin category members (including 1-Tetradecene) demonstrated sufficiently similar physico-chemical, environmental fate and toxicological properties to substantiate the basis for read-across; although category members of a carbon chain length C10 or greater may exhibit a reduced acute aquatic toxicity attributable to reduced water solubility, the environmental toxicity of all category member is expected to be manifested as non-polar narcosis. In addition, both 1-Tetradecene and Oct-2-ene are expected to exhibit sufficient adsorption to soil and sediment to exhibit similar long-term toxicity; therefore, read-across with respect to sediment and terrestrial toxicity endpoints is appropriate. Justification for inclusion of Oct-2-ene within the boundaries of the higher olefins category, and the relevance of each category member as an analogue substance to Oct-2-ene, is provided in Section 13 (Document name: “HOPA Higher Olefins CJD with Category Matrix Report [rev 1 Sept 2016]”; Document name: "ACC Product Stewardship Summary for Higher Olefins Category (2008-12-03)”). - Reason / purpose for cross-reference:
- read-across source
- Principles of method if other than guideline:
- conducted in accordance with PARCOM guidelines.
- GLP compliance:
- yes
- Remarks:
- No certificate
- Specific details on test material used for the study:
- Details on properties of test surrogate or analogue material (migrated information):
No data reported - Analytical monitoring:
- no
- Details on sampling:
- At the beginning, middle and end of the test the aeration system was removed and conductivity, pH, dissolved oxygen and temperatures were recorded. At the same time the number of animals on the sediment surface and any other additional information was recorded.
- Vehicle:
- yes
- Details on sediment and application:
- Collected from a point adjacent to the site of Corophium collection.
- Test organisms (species):
- Corophium volutator
- Details on test organisms:
- Obtained from Sebay, Mainland Orkney.
- Study type:
- laboratory study
- Test type:
- static
- Water media type:
- saltwater
- Type of sediment:
- natural sediment
- Duration:
- 10 d
- Exposure phase:
- total exposure duration
- Post exposure observation period:
- none
- Hardness:
- No data reported
- Test temperature:
- 14.3-15.9°C
- pH:
- 7.84-8.22
- Dissolved oxygen:
- 83-98%
- Salinity:
- 35‰
- Ammonia:
- No data reported
- Nominal and measured concentrations:
- Nominal concentrations of 13.46,128.62,1292.25, 4066.24 and 12397.57 mg/kg were pepared. (Calculated as mg/kg dry sediment, from the wet weight of sediment used and a wet:dry weight ratio of 1.36)
- Details on test conditions:
- The sediment was homogenised. Approx 20g of wet sediment was placed in a tared glass crystallising dish and weighed to ±0.01g. The dish and sediment were placed in a drying oven at approx 60°C for a minimum of 24h. After drying, the dish was re-weighed. The ratio of wet weight to dry weight was used to convert nominal exposure concentrations on a wet weight basis to nominal exposure concentrations on a dry weight basis. The test was conducted in 1-litre tall-form borosilicate glass beakers, each containing approximately 150ml (2cm depth) of sediment and 850ml filtered seawater. Replication = 3 per treatment. 5 controls. 20 organisms per replicate, 60 organisms per concentration. Test conducted under constant dim illumination. Conductivity 50.5-63.9 mS
- Key result
- Duration:
- 10 d
- Dose descriptor:
- LC50
- Effect conc.:
- 86.95 other: mg/kg
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks on result:
- other: 61.29-126.55
- Details on results:
- The number of animals responding after 10 days in each replicate was expresses as a proportion of the number exposed. The proportaion data were arcsin transformed, and the three replicate transformed values were averaged. The average values were back-transformed and an LC50 calculated from teh resulting proportion data using the moving average-angle method.
- Results with reference substance (positive control):
- No data reported
- Reported statistics and error estimates:
- Control mortality was 7% over the duration of the test.
- Validity criteria fulfilled:
- not specified
- Remarks:
- Insufficient data
- Conclusions:
- The 10 day LC50 for Corophium volutator was 86.95 mg/kg dry weight.
- Executive summary:
The 10 day LC50 for Corophium volutator was 86.95 mg/kg dry weight. This GLP study followed a standard guideline. No detail on the composition of the sediment is reported, and analytical monitoring was not included.This result gives an indication of the levels of 1-tetradecene that may cause sediment toxicity.
Reference
Description of key information
The key study was a static 10-d toxicity test on the effects of an analog substance on the marine amphipod, Corophium volutator following an OSPAR PARCOM guideline (Roddie, 1997). The 10-d LC50 was reported as 86.95 mg/kg d.w based on nominal concentrations.
Key value for chemical safety assessment
- EC50 or LC50 for marine water sediment:
- 86.95 mg/kg sediment dw
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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