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EC number: 203-455-5 | CAS number: 107-03-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1980-12-19 to 1981-01-20
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study with acceptable restrictions
- Remarks:
- The study is classified as reliable with restrictions because it complies with GLP and adheres to OECD guideline 405.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 981
- Report date:
- 1981
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Principles of method if other than guideline:
- Method: other: UBTL Protocol No. 01A-50
Similar to OECD 405 and OPPTS 870.2400 - GLP compliance:
- yes
Test material
- Reference substance name:
- Propane-1-thiol
- EC Number:
- 203-455-5
- EC Name:
- Propane-1-thiol
- Cas Number:
- 107-03-9
- Molecular formula:
- C3H8S
- IUPAC Name:
- propane-1-thiol
- Reference substance name:
- 1-PROPANE-1-THIOL
- IUPAC Name:
- 1-PROPANE-1-THIOL
Constituent 1
Constituent 2
Test animals / tissue source
- Species:
- rabbit
- Strain:
- New Zealand White
- Details on test animals or tissues and environmental conditions:
- TEST ANIMALS
- Source: University of Utah vivarium or other reputable breeder
- Housing: housed individually in wire cages with no sawdust or other dust producing material in the room.
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: 7 days
ENVIRONMENTAL CONDITIONS
- Temperature (°F): 70 +/- 3
- Humidity (%): 30 to 60
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12 hr / 12 hr
Test system
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- Amount applied: 0.1 ml
- Duration of treatment / exposure:
- 4 seconds
- Observation period (in vivo):
- 7 days
- Number of animals or in vitro replicates:
- 6
- Details on study design:
- Comment: not rinsed
SCORING SYSTEM: Draize
TOOL USED TO ASSESS SCORE: hand-held ophthalmoscope adn then with fluorescein
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- overall irritation score
- Remarks:
- Draize system
- Basis:
- mean
- Time point:
- other: 1 hr.
- Score:
- 8.3
- Max. score:
- 14
- Reversibility:
- fully reversible
- Irritation parameter:
- overall irritation score
- Remarks:
- Mean Draize score
- Basis:
- mean
- Time point:
- other: 24 hrs.
- Score:
- 2
- Max. score:
- 6
- Reversibility:
- fully reversible
- Irritation parameter:
- overall irritation score
- Remarks:
- Mean Draize score
- Basis:
- mean
- Time point:
- other: 48 hrs., 72 hrs.
- Score:
- 4.3
- Max. score:
- 24
- Reversibility:
- fully reversible
- Irritation parameter:
- overall irritation score
- Remarks:
- Mean Draize score
- Basis:
- mean
- Time point:
- other: 7 day
- Score:
- 0
- Max. score:
- 0
- Reversibility:
- fully reversible
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 6
- Remarks on result:
- no indication of irritation
- Remarks:
- Only total eye irritation scores were reported for individual animals from observations at 24/48/72 hours. Eye irritation was observed in 3 out of 6 animals. All eyes appeared normal by day 7 of the observation period. Therefore, it can be concluded that the test substance is Cat 2 eye irritant. Average maximum score 6 per endpoint.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.5
- Max. score:
- 6
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- positive indication of irritation
- Remarks:
- Only total eye irritation scores were reported for individual animals from observations at 24/48/72 hours. Eye irritation was observed in 3 out of 6 animals. All eyes appeared normal by day 7 of the observation period.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 6
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- positive indication of irritation
- Remarks:
- Only total eye irritation scores were reported for individual animals from observations at 24/48/72 hours. Eye irritation was observed in 3 out of 6 animals. All eyes appeared normal by day 7 of the observation period.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 4.5
- Max. score:
- 6
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- positive indication of irritation
- Remarks:
- Only total eye irritation scores were reported for individual animals from observations at 24/48/72 hours. Eye irritation was observed in 3 out of 6 animals. All eyes appeared normal by day 7 of the observation period.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 6
- Remarks on result:
- no indication of irritation
- Remarks:
- Only total eye irritation scores were reported for individual animals from observations at 24/48/72 hours. Eye irritation was observed in 3 out of 6 animals. All eyes appeared normal by day 7 of the observation period.
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 6
- Remarks on result:
- no indication of irritation
- Remarks:
- Only total eye irritation scores were reported for individual animals from observations at 24/48/72 hours. Eye irritation was observed in 3 out of 6 animals. All eyes appeared normal by day 7 of the observation period.
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 6
- Remarks on result:
- no indication of irritation
- Remarks:
- Only total eye irritation scores were reported for individual animals from observations at 24/48/72 hours. Eye irritation was observed in 3 out of 6 animals. All eyes appeared normal by day 7 of the observation period.
- Irritation parameter:
- iris score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.5
- Max. score:
- 6
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- positive indication of irritation
- Remarks:
- Only total eye irritation scores were reported for individual animals from observations at 24/48/72 hours. Eye irritation was observed in 3 out of 6 animals. All eyes appeared normal by day 7 of the observation period.
- Irritation parameter:
- iris score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 6
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- positive indication of irritation
- Remarks:
- Only total eye irritation scores were reported for individual animals from observations at 24/48/72 hours. Eye irritation was observed in 3 out of 6 animals. All eyes appeared normal by day 7 of the observation period.
- Irritation parameter:
- iris score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 4.5
- Max. score:
- 6
- Reversibility:
- fully reversible within:
- Remarks on result:
- positive indication of irritation
- Remarks:
- Only total eye irritation scores were reported for individual animals from observations at 24/48/72 hours. Eye irritation was observed in 3 out of 6 animals. All eyes appeared normal by day 7 of the observation period.
- Irritation parameter:
- iris score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 6
- Remarks on result:
- no indication of irritation
- Remarks:
- Only total eye irritation scores were reported for individual animals from observations at 24/48/72 hours. Eye irritation was observed in 3 out of 6 animals. All eyes appeared normal by day 7 of the observation period.
- Irritation parameter:
- iris score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 6
- Remarks on result:
- no indication of irritation
- Remarks:
- Only total eye irritation scores were reported for individual animals from observations at 24/48/72 hours. Eye irritation was observed in 3 out of 6 animals. All eyes appeared normal by day 7 of the observation period.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 6
- Remarks on result:
- no indication of irritation
- Remarks:
- Only total eye irritation scores were reported for individual animals from observations at 24/48/72 hours. Eye irritation was observed in 3 out of 6 animals. All eyes appeared normal by day 7 of the observation period.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.5
- Max. score:
- 6
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- positive indication of irritation
- Remarks:
- Only total eye irritation scores were reported for individual animals from observations at 24/48/72 hours. Eye irritation was observed in 3 out of 6 animals. All eyes appeared normal by day 7 of the observation period.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 6
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- positive indication of irritation
- Remarks:
- Only total eye irritation scores were reported for individual animals from observations at 24/48/72 hours. Eye irritation was observed in 3 out of 6 animals. All eyes appeared normal by day 7 of the observation period.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 4.5
- Max. score:
- 6
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- positive indication of irritation
- Remarks:
- Only total eye irritation scores were reported for individual animals from observations at 24/48/72 hours. Eye irritation was observed in 3 out of 6 animals. All eyes appeared normal by day 7 of the observation period.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 6
- Remarks on result:
- no indication of irritation
- Remarks:
- Only total eye irritation scores were reported for individual animals from observations at 24/48/72 hours. Eye irritation was observed in 3 out of 6 animals. All eyes appeared normal by day 7 of the observation period.
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 6
- Remarks on result:
- no indication of irritation
- Remarks:
- Only total eye irritation scores were reported for individual animals from observations at 24/48/72 hours. Eye irritation was observed in 3 out of 6 animals. All eyes appeared normal by day 7 of the observation period.
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 6
- Remarks on result:
- no indication of irritation
- Remarks:
- Only total eye irritation scores were reported for individual animals from observations at 24/48/72 hours. Eye irritation was observed in 3 out of 6 animals. All eyes appeared normal by day 7 of the observation period.
- Irritation parameter:
- chemosis score
- Basis:
- animal #2
- Time point:
- 24/48/72 h
- Score:
- 0.5
- Max. score:
- 6
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- positive indication of irritation
- Remarks:
- Only total eye irritation scores were reported for individual animals from observations at 24/48/72 hours. Eye irritation was observed in 3 out of 6 animals. All eyes appeared normal by day 7 of the observation period.
- Irritation parameter:
- chemosis score
- Basis:
- animal #3
- Time point:
- 24/48/72 h
- Score:
- 0.33
- Max. score:
- 6
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- positive indication of irritation
- Remarks:
- Only total eye irritation scores were reported for individual animals from observations at 24/48/72 hours. Eye irritation was observed in 3 out of 6 animals. All eyes appeared normal by day 7 of the observation period.
- Irritation parameter:
- chemosis score
- Basis:
- animal #4
- Time point:
- 24/48/72 h
- Score:
- 4.5
- Max. score:
- 6
- Reversibility:
- fully reversible within: 7 days
- Remarks on result:
- positive indication of irritation
- Remarks:
- Only total eye irritation scores were reported for individual animals from observations at 24/48/72 hours. Eye irritation was observed in 3 out of 6 animals. All eyes appeared normal by day 7 of the observation period.
- Irritation parameter:
- chemosis score
- Basis:
- animal #5
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 6
- Remarks on result:
- no indication of irritation
- Remarks:
- Only total eye irritation scores were reported for individual animals from observations at 24/48/72 hours. Eye irritation was observed in 3 out of 6 animals. All eyes appeared normal by day 7 of the observation period.
- Irritation parameter:
- chemosis score
- Basis:
- animal #6
- Time point:
- 24/48/72 h
- Score:
- 0
- Max. score:
- 6
- Remarks on result:
- no indication of irritation
- Remarks:
- Only total eye irritation scores were reported for individual animals from observations at 24/48/72 hours. Eye irritation was observed in 3 out of 6 animals. All eyes appeared normal by day 7 of the observation period.
Any other information on results incl. tables
The star (*) indicates the observation of a lesion
Summary of Individual Scores
|
Score |
Number of Animals with Eye Response |
|||||||
|
Unwashed |
Total |
|||||||
Animal Number |
562 |
563 |
564 |
569 |
570 |
590 |
Ave. |
Range |
|
Observation, Prescreen |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
1 hour |
4 |
4 |
14 |
10* |
6 |
12* |
8.3 |
4-12 |
6 |
24 hour |
0 |
2 |
4 |
6* |
0 |
0 |
2.0 |
0-6 |
3 |
48 hour |
0 |
2 |
0 |
24* |
0 |
0 |
4.3 |
0-24 |
2 |
72 hour |
0 |
2 |
0 |
24* |
0 |
0 |
4.3 |
0-24 |
2 |
4 day |
0 |
2 |
0 |
2* |
0 |
0 |
0.7 |
0-2 |
2 |
7 day |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
0 |
Combined average |
0.7 |
2.0 |
3.0 |
11.0 |
1.0 |
2.0 |
3.3 |
0.7-11 |
|
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- In this study, propane-1-thiol is an eye irritant in 3 out of 6 animals. All effects were fully reversible by day 7.
- Executive summary:
In a primary eye irritation study, 0.1 millilitres of propane-1-thiol was placed on the everted lower lid of the right eye of six New Zealand white albino rabbits for seconds and then released. The left eye remained untreated and served as a control. Eyes were not washed after exposure. Animals were observed for 7 days post dosing. Irritation was scored by the method of Draize.
Ocular irritation was observed in all of the test animals following exposure (mean irritation score = 8.3, 2.0, 4.3, and 4.3 for 1, 24, 48, and 72 hours respectively). All signs of irritation dissipated at the end of the 7 day observation period. The combined weight gain from day of dosing to day 7 was approximately 83 grams. In this study, propane-1-thiol is considered irritating to the eye based on the Draize method.
This study received a Klimisch score of 2 and is classified as reliable with restrictions because it complies with GLP and adheres closely to OECD guideline 405.
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