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EC number: 618-347-7 | CAS number: 9003-01-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- From 2016-10-27 to 2017-03-21
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- 2015-07-28
- Type of method:
- flask method
- Specific details on test material used for the study:
- - Composition of test material: 2-carboxyethyl acrylate oligomers (= homopolymers of acrylic acid + 2-carboxyethyl acrylate) and acrylic acid
- Analytical purity: >=99%
- Purity test date: 24 August 2016
- Lot/batch No.: BA5H22021
- Expiration date of the lot/batch: 24 August 2017
- Appearance: Colourless limpid liquid
- Storage: In darkness at room temperature
For the analysis, a different batch of the test item (BA5E47549) was used as reference item. - Key result
- Water solubility:
- > 104 g/L
- Conc. based on:
- other: acrylic acid monomers
- Temp.:
- 20 °C
- pH:
- ca. 3.23
- Key result
- Water solubility:
- > 488 g/L
- Conc. based on:
- other: 2-carboxyethyl acrylate oligomers
- Temp.:
- 20 °C
- pH:
- ca. 3.23
- Key result
- Water solubility:
- > 546 g/L
- Conc. based on:
- test mat.
- Temp.:
- 20 °C
- pH:
- ca. 3.23
- Details on results:
- The solubility in water of the test item is > 546 g/L at 20.0°C ± 1.0°C.
- Conclusions:
- The solubility in water of the test item was assessed to be > 546 g/L at 20.0°C ± 1.0°C.
- Executive summary:
The water solubility of the REACH substance was determined in a GLP-compliant study performed in accordance with EC A.6 method and OECD Guideline No. 105. The solubility in water of the test item was assessed to be > 546 g/L at 20.0°C ± 1.0°C.
Reference
Preliminary test
Through the serial volume addition of water to the test item, the following table shows the solubility in water of acrylic acid monomers and 2-carboxyethyl acrylate oligomers at 21.0 °C ± 1.0 °C.
Weight of test item (g) |
Volume of water (mL) |
Solubility (g/L) |
|
0.09855 |
0.1 |
Cloudy |
/ |
0.5 |
Cloudy |
/ |
|
1 |
Cloudy |
> 100 |
Main test
For acrylic acid monomers:
|
Reference of test solutions |
Peak area (area units) |
Conc. (mg/L) |
Mean Conc. (mg/L) |
Dil. factor |
Final conc. in acrylic acid monomers (g/L) |
Final conc. in test item (g/L) |
pH at 19°C |
|
|
|
|
C |
Df |
Cf |
Cf1 |
|
After 24h |
16-217 2A dil 16-217 2A dil |
9.2401 9.2232 |
5.13 5.12 |
5.13 |
20000 |
102.6 |
539.8 |
3.27 |
16-217 2B dil 16-217 2B dil |
9.3070 9.2943 |
5.17 5.16 |
5.17 |
20000 |
103.3 |
543.8 |
3.24 |
|
After 48h |
16-217 2C dil 16-217 2C dil |
9.6673 9.6742 |
5.37 5.37 |
5.37 |
20000 |
107.4 |
565.2 |
3.24 |
16-217 2D dil 16-217 2D dil |
9.2982 9.3001 |
5.16 5.17 |
5.17 |
20000 |
103.3 |
543.7 |
3.22 |
|
After 72h |
16-217 2E dil 16-217 2E dil |
9.2730 9.2388 |
5.15 5.13 |
5.14 |
20000 |
102.8 |
541.2 |
3.23 |
16-217 2F dil 16-217 2F dil |
9.2432 9.2166 |
5.13 5.12 |
5.13 |
20000 |
102.5 |
539.7 |
3.19 |
|
|
|
|
|
|
Mean |
104 |
546 |
|
|
|
|
|
|
SD |
2 |
10 |
|
|
|
|
|
|
RSD (%) |
1.79 |
1.79 |
|
For 2 -carboxyethyl acrylate oligomers
|
Reference of test solutions |
Peak area (area units) |
Conc. (mg/L) |
Mean Conc. (mg/L) |
Dil. factor |
Final conc. in 2-carboxyethyl acrylate oligomers (g/L) |
Final conc. in test item (g/L) |
pH at 19°C |
|
|
|
|
C |
Df |
Cf |
Cf1 |
|
After 24h |
16-217 2A dil 16-217 2A dil |
24.6232 24.4973 |
24.28 24.16 |
24.2 |
20000 |
484.3 |
578.0 |
3.27 |
16-217 2B dil 16-217 2B dil |
24.6516 24.7324 |
24.31 24.38 |
24.3 |
20000 |
486.9 |
581.0 |
3.24 |
|
After 48h |
16-217 2C dil 16-217 2C dil |
25.6200 25.7176 |
25.24 25.34 |
25.3 |
20000 |
505.8 |
603.6 |
3.24 |
16-217 2D dil 16-217 2D dil |
24.6047 24.6973 |
24.26 24.35 |
24.3 |
20000 |
486.1 |
580.1 |
3.22 |
|
After 72h |
16-217 2E dil 16-217 2E dil |
24.5501 24.5982 |
24.21 24.25 |
24.2 |
20000 |
484.6 |
578.3 |
3.23 |
16-217 2F dil 16-217 2F dil |
24.5364 24.4194 |
24.19 24.08 |
24.1 |
20000 |
482.8 |
576.1 |
3.19 |
|
|
|
|
|
|
Mean |
488 |
583 |
|
|
|
|
|
|
SD |
9 |
10 |
|
|
|
|
|
|
RSD (%) |
1.77 |
1.77 |
|
Conclusion
The following table shows the solubility in water of the test item performed at 20.0°C ± 1.0°C.
Solubility in water test item (g/L) |
Expressed as acrylic acid monomers |
Expressed as 2-carboxyethyl acrylate oligomers |
Expressed as test item |
> 104 |
> 488 |
> 546 |
Description of key information
The water solubility of the REACH substance was determined in a GLP-compliant study performed in accordance with EC A.6 method and OECD Guideline No. 105. The solubility in water of the test item was assessed to be > 546 g/L at 20.0°C ± 1.0°C.
Key value for chemical safety assessment
- Water solubility:
- 546 g/L
- at the temperature of:
- 20 °C
Additional information
The water solubility of the REACH substance was determined in a GLP-compliant study performed in accordance with standard methods, without deviations. The study is considered as reliable (Klimisch 1) and is selected as a key study for the endpoint.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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