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EC number: 229-942-2 | CAS number: 6850-63-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
Short-term toxicity to fish:
The toxic effect of 2,6-dimethylcyclohexylamine (CAS 6850-63-1) was studied in a non-GLP test according to German Industrial Standard DIN 38412 part 15 performed under static conditions with Leuciscus idus as test species (BASF AG, 1987; report no.: 87/192). After 96 hours of exposure a LC50 of 22 to 46 mg/L (geometric mean 31,8 mg/L) was determined, based on nominal concentrations.
The substance is concluded to be acutely harmful to fish.
Short-term toxicity to aquatic invertebrates:
Acute toxic effects of 2,6-dimethylcyclohexylamine (CAS 6850-63-1) to aquatic invertebrates were studied in a non-GLP study following the method laid down in Directive 79/831/EEC method C.2 using Daphnia magna as test species (BASF AG, 1987; report no.: 1/0306/2/87-0306). Based on nominal test concentrations the 48-h EC50 was determined to be 36.29 mg/L.
2,6-dimethylcyclohexylamine is concluded to be acutely harmful to aquatic invertebrates.
Toxicity to aquatic algae and cyanobacteria:
In a non-GLP, 96-hour static test with the green alga Scenedesmus subspicatus (new name: Desmodesmus subspicatus) according to German Industrial Standard DIN 38412 part 9, the algae toxicity of2,6-dimethylcyclohexylaminewas investigated. Statistical re-evaluation of the endpoint growth rate revealed an EC50 (72h) of 48.6 mg/L, the EC10 (72h) was estimated to be 28.1 mg/L, both related to nominal test concentrations.
In conclusion, the substance is acutely harmful to aquatic algae and cyanobacteria.
Toxicity to microorganisms:
The assessment of the toxicity of 2,6-dimethylcyclohexylamine (CAS 6850-63-1) to aquatic microorganisms is based on experimental data from a test performed by BASF AG (1987; report no.: 9/0556/87) according to German Industrial Standard DIN 38412 part 8 was, using Pseudomonas putida as test organism. Based on growth inhibition a 17-h EC10 and 17-h EC50 were determined to be 138.1 mg/L and 188.3 mg/L, respectively.
In addition, there are supporting data available from a short-term respiration inhibition test conducted according to ISO 8192 (BASF AG, 1987; report no.: 01.269/87). In this limit test, the 30-min EC20 was determined to be >659 mg/L based on nominal test concentrations. As inoculum, industrial activated sludge was used.
According to the REACH guidance document (ECHA, 2016) chapter R.7b the results of a cell multiplication inhibition test with P. putida (Bringmann and Kühn, 1980; ISO 10712, 1996) should be used for calculation of the PNECmicro-organisms in cases where no other test results are available. However, as the short-term respiration inhibition test was performed with industrial activated sludge as inoculum, the results of the single-organism test with P. putida were selected as key data for chemical safety assessment (PNEC derivation).
In summary, it can be concluded that inhibition of the degradation activity of activated sludge is not anticipated when introduced in appropriately low concentrations.
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