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EC number: 201-137-0 | CAS number: 78-73-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Partition coefficient
Administrative data
Link to relevant study record(s)
Description of key information
Partition coefficient:
-3.77 (OECD 123, shake-flask method, Choline chloride)
-2.25 (OECD 107, shake-flask method, Choline hydroxide)
Key value for chemical safety assessment
Additional information
Provided that the test substance a salt, in aqueous solution it is present in the dissociated form: choline and bicarbonate ions.
As reported in "Guidance on information requirements and chemical safety assessment Chapter R.7a: Endpoint specific guidance (Version 2.0, November 2012)" R.7.1.8.4 about Partition Coefficient”: The study does not need to be conducted if the substance is inorganic.
Therefore for bicarbonate ions it is not necessary to determine the partition coefficient.
As far as the partition coefficient n-octanol/water of choline ion is concerned, the information requirements should refer to the LogPow of the test substance as is. Since the choline cation is organic, the logPow should be however taken into consideration.
There are two experimental results available for choline salts with inorganic anions, Choline chloride and Choline hydroxide. For both anions, a clearly negative logPow is to be expected. Due to its organic, albeit ionic structure, it is reasonable to assume that the choline cation has a higher solubility in octanol than the corresponding anions. Hence the height of the available logPow, i.e. -3.77 (Choline chloride) and -2.25 (Choline hydroxide), is mainly attributed to the organic cation and can be considered to be transferrable as a worst case scenario without modifications to the choline cation of Choline bicarbonate.
This approach is considered reasonable as the value of the Pow is in a magnitude clearly demonstrating that no bioaccumulative potential or relevant dermal resorption via the stratum corneum is given. So, in this case, the read-across for a physico-chemical property is justified, the tonnage-driven data requirements under REACH are met and no further testing is required.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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