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Diss Factsheets
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EC number: 604-047-3 | CAS number: 137863-20-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- July - Octobet 1994
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- yes
- Analytical monitoring:
- yes
- Details on sampling:
- Composite samples of each test concentration were drawn by mixing identical volumes of the test solutions taken from the approximate center of the test vessels. They were taken immediately before exposure and after 48 hours exposure and kept at - 18°C to - 22°c until analysis.
- Vehicle:
- yes
- Remarks:
- 30.7 mg N,N-dimethylformamide (DMF)/l and 1.3 mg polyoxy- ethylene-sorbitan-monooleate (TWEEN 80) /l per liter
- Details on test solutions:
- Nominal: 1.8, 3.2, 5.8, 10, 18 and 32 mg test substance/I
Calculated amounts of the stock solution to produce the desired test concentrations and vehicle to achieve identical vehicle concentrations were given into the water and were homogeneously distributed. The daphnia were then transferred into the beakers. The test substance was homogeneously distributed in the test vessels at all test times and test concentrations. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- No. of Daphnia: 20 per concentration and control. 4 replicates of 5 daphnia each.
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Hardness:
- 240 mg CaC03/l
- Test temperature:
- 21 - 22 °C
- pH:
- 7.9
- Dissolved oxygen:
- 99 - 103
- Nominal and measured concentrations:
- Nominal test concentrations: control, 1.8, 3.2, 5.8, 10, 18, 32 mg/L
Mean recovery rates: 88-95% - Key result
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- 10 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- 22 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC100
- Effect conc.:
- 32 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Validity criteria fulfilled:
- not specified
- Conclusions:
- Values calculated
EC 50 (48 h) 22 mg/l
95 % confidence limit 19 - 27 mg/l
Goodness of fit CHI 4.36
EC 50 (24 h) 24 mg/l
95 % confidence limit 21 - 29 mg/l
Goodness of fit CHI 1. 26
Values graphically determined
EC 50 ( 48 h ) 22 mg/l
Values observed
NOEC ( 48 h ) 10 mg/l
EC O ( 48 h ) 10 mg/l
EC 100 ( 48 h ) 32 mg/l
Controls
Immobilizations in blank 0
Immobilizations in vehicle 0
Reference
Description of key information
Values calculated
EC 50 (48 h) 22 mg/l
95 % confidence limit 19 - 27 mg/l
Goodness of fit CHI 4.36
EC 50 (24 h) 24 mg/l
95 % confidence limit 21 - 29 mg/l
Goodness of fit CHI 1. 26
Values graphically determined
EC 50 ( 48 h ) 22 mg/l
Values observed
NOEC ( 48 h ) 10 mg/l
EC O ( 48 h ) 10 mg/l
EC 100 ( 48 h ) 32 mg/l
Controls
Immobilizations in blank 0
Immobilizations in vehicle 0
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 22 mg/L
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.