Registration Dossier
Registration Dossier
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EC number: 223-051-2 | CAS number: 3709-43-1
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- GCID : 221778
- Year:
- 2 011
- Bibliographic source:
- ACToR (Aggregated Computational Toxicology Resource);JAPAN CHEMICAL INDUSTRY ECOLOGY- TOXICOLOGY AND INFORMATION CENTER, JAPAN;(SUPPL. 2), 2000
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Method : PREINCUBATION
- GLP compliance:
- not specified
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- Disodium 4,4'-dinitrostilbene-2,2'-disulphonate
- EC Number:
- 223-051-2
- EC Name:
- Disodium 4,4'-dinitrostilbene-2,2'-disulphonate
- Cas Number:
- 3709-43-1
- Molecular formula:
- C14H10N2O10S2.2Na
- IUPAC Name:
- disodium 4,4'-dinitrostilbene-2,2'-disulphonate
- Details on test material:
- - Name of test material (as cited in study report): disodium 4,4'-dinitrostilbene-2,2'-disulphonate
- Substance type: Organic
- Physical state: Solid
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- S. typhimurium TA 98
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- with and without
- Metabolic activation system:
- RAT LIVER S-9, PHENOBARBITAL AND BETA-NAPHTHOFLAVONE
- Test concentrations with justification for top dose:
- 0.61-10000 UG/PLATE
Results and discussion
Test results
- Species / strain:
- S. typhimurium TA 98
- Metabolic activation:
- with and without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
disodium 4,4'-dinitrostilbene-2,2'-disulphonate was not genetically toxic at up to concentration 0.61-10000 UG/PLATE - Executive summary:
AMES test conducted with disodium 4,4'-dinitrostilbene-2,2'-disulphonate up to the concentration of 0.61-10000 micrograms per plate did not exhibit genotoxicity in Salmonella typhimurium TA98.
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