Registration Dossier
Registration Dossier
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EC number: 223-051-2 | CAS number: 3709-43-1
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation
- Remarks:
- in vivo
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- Danish QSAR study for CAS No.: 3709-43-1
- Author:
- Danish EPA Model
- Year:
- 2 012
- Bibliographic source:
- QSAR predictions by Danish Environmental Protection Agency (EPA)model powered by OASIS database:-Commercial
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: Modelling database
- Principles of method if other than guideline:
- Data is from Multicase model A33.
- GLP compliance:
- no
- Type of study:
- not specified
Test material
- Reference substance name:
- Disodium 4,4'-dinitrostilbene-2,2'-disulphonate
- EC Number:
- 223-051-2
- EC Name:
- Disodium 4,4'-dinitrostilbene-2,2'-disulphonate
- Cas Number:
- 3709-43-1
- Molecular formula:
- C14H10N2O10S2.2Na
- IUPAC Name:
- disodium 4,4'-dinitrostilbene-2,2'-disulphonate
- Details on test material:
- - Name of test material (as cited in study report): disodium 4,4'-dinitrostilbene-2,2'-disulphonate
- Substance type: Organic
- Physical state: Solid
Constituent 1
In vivo test system
Test animals
- Species:
- human
- Sex:
- not specified
Study design: in vivo (non-LLNA)
Induction
- Route:
- other: no data
- Vehicle:
- no data
Challenge
- Route:
- other: no data
- Vehicle:
- no data
Results and discussion
In vivo (non-LLNA)
Results
- Clinical observations:
- Skin sensitization: NEGATIVE
- Remarks on result:
- other: Clinical observations: Skin sensitization: NEGATIVE.
Any other information on results incl. tables
Skin sensitization : NEGATIVE
Applicant's summary and conclusion
- Interpretation of results:
- not sensitising
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- Skin sensitization of disodium 4,4'-dinitrostilbene-2,2'-disulphonate showed negative result
- Executive summary:
According to Danish QSAR using multicase model estimated that disodium 4,4'-dinitrostilbene-2,2'-disulphonate is not sensatising to skin.
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