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EC number: 604-759-4 | CAS number: 150928-21-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Toxicity to microorganisms
Administrative data
- Endpoint:
- toxicity to microorganisms, other
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Apr 1993
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1994
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- DIN 38412-8 (Pseudomonas Zellvermehrungshemmtest)
- Version / remarks:
- Mar 1991
- GLP compliance:
- yes
Test material
- Reference substance name:
- rac-3-(2,3-Diacetoxypropylcarbamoyl)-2,4,6-triiodo-5-methoxyacetylaminobenzoyl chloride
- EC Number:
- 604-759-4
- Cas Number:
- 150928-21-5
- Molecular formula:
- C18 H18 Cl I3 N2 O8
- IUPAC Name:
- rac-3-(2,3-Diacetoxypropylcarbamoyl)-2,4,6-triiodo-5-methoxyacetylaminobenzoyl chloride
Constituent 1
Sampling and analysis
- Analytical monitoring:
- yes
- Remarks:
- DOC
Test solutions
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: For the stock solution 5 g of ZK 91.445 were suspended in 500 mL of sterile demineralized water. This solution was used for the highest concentration after ultrasonification and filtration. For the lower test concentrations, the stock solution was diluted 1:2 and 1:4. 80 mL of the respective solution were filled into the respective test vessel. In the filtered stock solution a DOC value of 136 mg/L was found corresponding to 523 mg/L ZK 91.445. Thus, the DOC measurements showed that only approximately 5% of the nominal concentration was dissolved in aqueous solution.
- Eluate: no
- Differential loading: np
- Controls: yes, test medium control
Test organisms
- Test organisms (species):
- Pseudomonas putida
- Details on inoculum:
- - Source: obtained from the "Deutsche Sammlung für Mikroorganismen, Göttingen", Germany
- Cultivation: ad kept on slant agar containing a nutrient solution at approximately 25°C. During culturing the microorganisms were transferred weekly.
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 16 h
Test conditions
- Test temperature:
- 25 °C
- Nominal and measured concentrations:
- nominal: control, 131, 262, 523 mg/L
- Details on test conditions:
- TEST SYSTEM
- Aeration: constanly shaken
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: according to guideline
EFFECT PARAMETERS MEASURED (with observation intervals if applicable): The turbidity of the control was measured at 0 and 16 hours, whereas the turbidity of the test concentrations was measured only after 16 hours. Additionally, measurements of the control and the test concentrations without inoculum were performed after 16 hours. All measurements were made at a wave-Iength of 436 nm. - Reference substance (positive control):
- no
Results and discussion
Effect concentrations
- Key result
- Duration:
- 16 h
- Dose descriptor:
- other: TE/F units
- Effect conc.:
- > 523 mg/L
- Nominal / measured:
- meas. (initial)
- Conc. based on:
- test mat.
- Basis for effect:
- growth inhibition
Applicant's summary and conclusion
- Validity criteria fulfilled:
- not applicable
- Conclusions:
- No effects on growth of Pseudomonas putida.
- Executive summary:
The results of the growth inhibition test with Pseudomonas putida demonstrate that a solution of ZK 91.445 up to approximately 500 mg/L has no relevant effects on the bacterial growth after 16 h of exposure. However, it has to be taken into account that the compound hydrolyses in aqueous solutions and the results reflect the exposure to the parent compound as well as to the products of hydrolysis.
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