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EC number: 604-759-4 | CAS number: 150928-21-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to fish
Administrative data
- Endpoint:
- short-term toxicity to fish
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Mar 1993
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 203 (Fish, Acute Toxicity Test)
- Version / remarks:
- adopted 4 Apr 1984
- GLP compliance:
- yes
Test material
- Reference substance name:
- rac-3-(2,3-Diacetoxypropylcarbamoyl)-2,4,6-triiodo-5-methoxyacetylaminobenzoyl chloride
- EC Number:
- 604-759-4
- Cas Number:
- 150928-21-5
- Molecular formula:
- C18 H18 Cl I3 N2 O8
- IUPAC Name:
- rac-3-(2,3-Diacetoxypropylcarbamoyl)-2,4,6-triiodo-5-methoxyacetylaminobenzoyl chloride
Constituent 1
Sampling and analysis
- Analytical monitoring:
- no
Test solutions
- Details on test solutions:
- PREPARATION AND APPLICATION OF TEST SOLUTION (especially for difficult test substances)
- Method: 240 g of the test substance were dissolved in 800 mL of tap water and dispersed using an ultrasonic bath for approximately 1 hour. After addition of tap water up to a final volume of 24 L the dispersion was stirred for approximately 4 hours and then left for approximately 72 hours. 20 L were then decanted and used as test solution. The control group was held in 20 L of tap water.
- Eluate: no
- Differential loading: yes
- Controls: yes, test medium control
Test organisms
- Test organisms (species):
- Danio rerio (previous name: Brachydanio rerio)
- Details on test organisms:
- TEST ORGANISM
- Common name: Zebra fish
- Strain: Westaquarium, Zierfischzüchterei, Bad Lauterberg
- Age at study initiation (mean and range, SD): 2.5 cm
ACCLIMATION
- Acclimation period: 14 days
- Acclimation conditions (same as test or not): same
- Type and amount of food during acclimation: twice a day
- Feeding frequency during acclimation: twice a day
- Health during acclimation (any mortality observed): no mortalities
Study design
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
Test conditions
- Test temperature:
- 21°C ± 1°C
- pH:
- 6.9 - 7.9
- Dissolved oxygen:
- 7.3 - 8.6 mg/L
- Nominal and measured concentrations:
- nominal: control, 10 g/L
- Details on test conditions:
- TEST SYSTEM
- Test vessel: 21 L glass aquaria
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 2
- No. of vessels per control (replicates): 2
TEST MEDIUM / WATER PARAMETERS
- Source/preparation of dilution water: according to guideline
OTHER TEST CONDITIONS
- Photoperiod: 12 h light / 12 h darkness
EFFECT PARAMETERS MEASURED (with observation intervals if applicable)
- Mortality was recorded after 2, 24 and 48 h - Reference substance (positive control):
- not required
Results and discussion
Effect concentrations
- Key result
- Duration:
- 48 h
- Dose descriptor:
- LC50
- Effect conc.:
- > 10 g/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality (fish)
Applicant's summary and conclusion
- Conclusions:
- LC50 (48 h) > 10 g/L
- Executive summary:
Ten Zebra fish each were exposed to one concentration of ZK 91.445 and the dilution water for a period of 48 hours under static conditions. The following nominal test concentration was selected: 10.0 g/L. Mortalities and visual abnormalities were recorded at 2, 24 and 48 hours. The light/dark rhythm was adjusted to 12 hours/12 hours. No mortality was observed in the test concentration within 48 hours. No fish showed any abnormal behaviour in the treatment solution over 48 hours. According to a stability analysis of ZK 91.445 in an aqueous solution, the test compound is unstable and it is assumed that the test material was degraded to a substantial degree during the exposure period. There was still a slight precipitate at the beginning of the test, which was removed by decanting. However, during the exposure the concentration of the parent compound diminished. Thus, the test comprises the effect of the metabolites and the parent substance.
The study resulted in a LC50 (48 h) > 10 g/L. The exposure duration is not in line with today’s standard methods. However, since no effects were recorded at a saturated solution after 48 h it is unlikely that a test with a duration of 96 h results in a different outcome.
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