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Registration Dossier
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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 947-155-9 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- genetic toxicity in vivo, other
- Data waiving:
- study scientifically not necessary / other information available
- Justification for data waiving:
- other:
- Justification for type of information:
- JUSTIFICATION FOR DATA WAIVING
A dubious result was obtained in the chromosomal aberration study conducted with the source substance (IOA) where a response indicating a possible interaction with DNA was only identified at a single, cytotoxic (50%) dose level with a 48 hour exposure without metabolic activation. All other dose levels, exposure lengths and metabolic activation combinations were negative for clastogenicity.
In general, substances containing acrylate functional groups have been documented to exert a cytotoxic, non-genotoxic mechanism of action in in vitro genotoxicity/mutageniciy assays. This is illustrated in the review article "A review of the genotoxic, mutagenic, and carcinogenic potentials of several lower acrylates" (Suh et al., 2018) which highlights positive responses with a variety of lower molecular weight acrylates solely at cytotoxic doses. In cases where a positive response was observed in an in vitro chromosome aberration study, follow-up in vivo testing was negative, supporting the cytotoxicity rather than genotoxicity mechanism of action. The authors concluded: "Toxicokinetic data demonstrate that these acrylates are metabolized rapidly by carboxylesterase hydrolysis and conjugation with glutathione. Overall, the genotoxicity and mutagenicity data support a cytotoxic, non-genotoxic mechanism for these acrylates." (Suh et al., 2018)
Additionally, higher molecular weight acrylates like EC 947-818-2 (REACH registered, dossier submitter is the owner of EC 947-818-2 data) were found to be negative in a bacterial reverse mutation assay, chromosome aberration study and mouse lymphoma assay further supporting the non-genotoxic effects for acrylates.
Against this background and in conformity with ECHA's principle of avoiding unnecessary animal testing, it is considered unnecessary to perform an in vivo genotoxicity/mutagenicity study.
Supporting References:
Suh, M, Proctor, D, Chappell, G, Rager, J, Thompson, C, Borghoff, S, Finch, L, Ellis-Hutchings, R, Wiench, K (2018) A review of the genotoxic, mutagenic, and carcinogenic potential os several lower acrylates. Toxicology 402-403:50-67.
REACH Registration of EC 947-818-2.
Data source
Materials and methods
Test material
- Reference substance name:
- Reactionmass of octan-2-yl prop-2-enoate and octan-3-yl prop-2-enoate and octan-4-yl prop-2-enoate
- EC Number:
- 947-155-9
- Molecular formula:
- C11H20O2
- IUPAC Name:
- Reactionmass of octan-2-yl prop-2-enoate and octan-3-yl prop-2-enoate and octan-4-yl prop-2-enoate
- Test material form:
- liquid
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Results and discussion
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.