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EC number: 209-127-8 | CAS number: 556-50-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- None
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
- Remarks:
- Although the study has not been performed in accordance with any guideline, its results are very comparable with other literary sources
Data source
Reference
- Reference Type:
- publication
- Title:
- Densities and solubilities of glycylglycine and glycyl-l-alanine in aqueous electrolyte solutions
- Author:
- Breil MP, Mollerup JM, Rudolph ESJ, Ottens M, van der Wielen LAM
- Year:
- 2 004
- Bibliographic source:
- Fluid Phase Equilibria 215: 221–225
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Glycylglycine was added in abundance to ensure saturation, followed by a defined time of stirring in a thermostated water bath and subsequent filtration to separate excess test material.
- GLP compliance:
- no
- Type of method:
- flask method
Test material
- Reference substance name:
- N-glycylglycine
- EC Number:
- 209-127-8
- EC Name:
- N-glycylglycine
- Cas Number:
- 556-50-3
- Molecular formula:
- C4H8N2O3
- IUPAC Name:
- N-glycylglycine
- Test material form:
- solid
- Details on test material:
- Purchased from Bachem A.G. (Bubendorf, Switzerland)
Constituent 1
Results and discussion
Water solubility
- Key result
- Water solubility:
- 1.74 other: mol/kg water
- Conc. based on:
- test mat. (dissolved fraction)
- Incubation duration:
- >= 18 - <= 24 h
- Temp.:
- 298.15 K
- pH:
- 5.65
- Remarks on result:
- other: The pH was calculated based on theoretical considerations.
- Details on results:
- The densitiy of this saturated glycylglycine-water solution indicated as key result was determined to be 1.0776 g cm-3.
Any other information on results incl. tables
Solubility and density of saturated glycylglycine solutions in the presence of different NaCl concentrations:
NaCl (mol/kg H2O) |
density(sat.sol.) (g/cm3) |
Solubility (mol/kg H2O) |
0.1003 |
1.0807 |
1.73 |
1.0825 |
1.76 |
|
0.2012 |
1.0841 |
1.74 |
1.0869 |
1.80 |
|
0.4041 |
1.0856 |
1.80 |
1.0943 |
1.83 |
|
0.5071 |
1.0984 |
1.85 |
1.0985 |
1.84 |
|
0.6082 |
1.1024 |
1.87 |
1.1021 |
1.85 |
|
0.8151 |
1.1098 |
1.87 |
1.1095 |
1.89 |
|
0.9182 |
1.1130 |
1.88 |
1.1129 |
1.88 |
|
1.0217 |
1.1163 |
2.10 |
1.1162 |
1.89 |
|
2.0436 |
1.98 |
|
3.0061 |
1.97 |
|
3.9870 |
2.01 |
|
4.9859 |
2.07 |
|
5.5928 |
2.10 |
|
5.6093 |
2.12 |
|
5.6202 |
2.08 |
|
5.6300 |
2.10 |
|
6.0279 (saturation) |
2.12 |
|
6.0503 (saturation) |
2.16 |
Solubility and density of saturated glycylglycine solutions in the presence of different Na2SO4 concentrations:
Na2SO4 (mol/kg H2O) |
density(sat.sol.) (g/cm3) |
Solubility (mol/kg H2O) |
0.1003 |
1.0920 |
1.84 |
|
1.0914 |
1.82 |
0.1735 |
1.1042 |
1.89 |
|
1.1042 |
1.85 |
0.2012 |
1.1213 |
1.91 |
|
1.1201 |
1.88 |
0.3524 |
1.1005 |
2.01 |
|
1.0996 |
1.94 |
0.5054 |
1.1376 |
2.11 |
|
1.1376 |
1.97 |
0.6078 |
1.1478 |
2.09 |
|
1.1469 |
2.00 |
0.8146 |
1.1669 |
2.03 |
|
1.1665 |
2.00 |
1.0241 |
1.1860 |
2.07 |
|
1.1850 |
2.03 |
Solubility and density of saturated glycylglycine solutions in the presence of different (NH4)2SO4 concentrations:
(NH4)2SO4 (mol/kg H2O) |
density(sat.sol.) (g/cm3) |
Solubility (mol/kg H2O) |
0.1012 |
1.0878 |
1.82 |
|
1.0868 |
1.81 |
0.2028 |
1.0958 |
1.89 |
|
1.0951 |
1.87 |
0.4095 |
1.1102 |
2.00 |
|
1.1093 |
1.98 |
0.5150 |
1.1169 |
2.05 |
|
1.1155 |
2.01 |
0.6217 |
1.1237 |
2.07 |
|
1.1223 |
2.05 |
0.8411 |
1.1344 |
2.12 |
|
1.1331 |
2.07 |
0.9524 |
1.1401 |
2.12 |
|
1.1389 |
2.08 |
1.0652 |
1.1452 |
2.14 |
|
1.1439 |
2.10 |
Applicant's summary and conclusion
- Conclusions:
- In this study, the water solubility of glycylglycine was determined to be 1.74 mol/kg water at 298.15 K and pH 5.65. In the presence of increasing salt concentrations of NaCl, Na2SO4 and (NH4)2SO4, the solubility of glycylglycine increases moderately.
- Executive summary:
Breil et al. (2004) determined the water solubility of glycylglycine in pure water as well as in aqueous electrolyte solutions at various salt concentrations of NaCl, Na2SO4 and (NH4)2SO4.
To this end, glycylglycine was added in abundance to the solutions consisting either of pure water or different salt concentrations dissolved in water to ensure saturation. These solutions were subsequently stirred for 18 to 24 hours at 298.15 K . After equilibration, samples were taken and filtered to separate excess test item. The concentration of test item was subsequently determined by spectrophotometry.
The water solubility of glycylglycine was determined to be 1.74 mol/kg water at 298.15 K and pH 5.65. In the presence of increasing salt concentrations of NaCl, Na2SO4 and (NH4)2SO4, the solubility of glycylglycine increases moderately.
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