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EC number: 217-588-1 | CAS number: 1897-45-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 12 Jan 2000 to 27 Jan 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Version / remarks:
- 1987
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Version / remarks:
- 1992
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1200 (Acute Dermal Toxicity)
- Version / remarks:
- 1998
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Chlorothalonil
- EC Number:
- 217-588-1
- EC Name:
- Chlorothalonil
- Cas Number:
- 1897-45-6
- Molecular formula:
- C8Cl4N2
- IUPAC Name:
- tetrachlorobenzene-1,3-dicarbonitrile
Constituent 1
Test animals
- Species:
- rat
- Strain:
- other: Alpk:APfSD
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: 8 to 12 weeks
- Weight at study initiation: Males: 352-393 g. Females: 211-249 g
- Housing: The rats were housed individually, in cages suitable for animals of this strain and the weight range expected during the course of the study.
- Diet: Ad libitum
- Water: Ad libitum
- Acclimation period: At least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22 ± 3
- Humidity (%): 30 to 70
- Air changes (per hr): A minimum of 15
- Photoperiod (hrs dark / hrs light): 12/12
IN-LIFE DATES: From: 12 Jan 2000 To: 27 Jan 2000
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- The day prior to application of the test substance, the hair was removed with a pair of veterinary clippers from an area, at least 7 cm x 7 cm, on the dorso-lumbar region of each animal. The appropriate amount of the test substance was weighed onto a plastic weighing boat and, to allow good skin contact, was moistened to a dry paste with a small amount (0.9 - 1.3 mL) of water. The amount applied was calculated for each animal according to its weight at the time of dosing. The estimated amount applied per unit area of skin exposed was 47.9 - 53.5 mg/cm2 for males and 28.6 - 33.8 mg/cm2 for females.
The test substance was applied to the shorn back of each animal and was kept in contact with the skin for approximately 24 hours using an occlusive dressing wrapped around the trunk of the animal. Each dressing consisted of a foil backed gauze patch to cover the treated area and was held in position by a cohesive bandage secured with two pieces of surgical tape.
At the end of the 24-hour contact period, the dressings were carefully cut, using blunt tipped scissors, removed and discarded. The skin, at the site of application, was cleansed free of any residual test substance using clean swabs of absorbent cotton wool soaked in clean warm water and was then dried gently with clean tissue paper. - Duration of exposure:
- 24 hours
- Doses:
- 5000 mg/kg bw/day
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- CLINICAL OBSERVATIONS
Prior to the start of the study, all rats were examined to ensure that they were physically normal and exhibited normal activity. The animals were observed twice following dosing on day 1 (only gross abnormalities were noted at this time as the presence of the dressings may have affected the behaviour and movement of the rats). Subsequent observations for signs of systemic toxicity and skin irritation were made once daily up to day 15.
BODY WEIGHTS
The animals were weighed immediately before dosing (day 1) and on days 8 and 15.
TERMINATION
All rats were killed by exsanguination under terminal anaesthesia induced by halothane vapour.
MACROSCOPIC EXAMINATION
All animals were examined post mortem. This involved an external observation and a careful examination of all thoracic and abdominal viscera. All abnormalities were recorded but tissues were not submitted for histopathological examination. - Statistics:
- The acute dermal median lethal dose was estimated from the mortality data.
Results and discussion
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- >= 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- None of the animals died and there were no significant signs of systemic toxicity.
- Clinical signs:
- other: Slight or moderate skin irritation was seen in all animals. Signs of skin irritation had resolved in all the females by day 14, but was still apparent in four of the males at the end of the study.
- Gross pathology:
- At examination post mortem, compound-related abnormalities comprised scabs at the application site of two males. One male had stained nares. This is considered to be a non-specific finding which is incidental to treatment.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on this study, the acute dermal median lethal dose of the test substance is estimated to be in excess of 5000 mg/kg to male and female rats.
- Executive summary:
A group of five male and five female Alpk:APfSD (Wistar-derived) rats received a single 24 hour dermal application of 5000 mg/kg of the test substance (OECD 402, GLP). The animals were assessed daily for the following 14 days for any signs of systemic toxicity and their body weights were recorded at intervals throughout the study. At the end of the study all the animals were killed and subjected to a macroscopic examination post mortem.
None of the animals died and there were no significant signs of systemic toxicity. All except one animal showed an overall body weight gain during the study. At examination post mortem, compound-related abnormalities comprised scabs at the application site of two males. Slight or moderate skin irritation was seen in all animals. Signs of skin irritation had resolved in all the females by day 14, but was still apparent in four of the males at the end of the study.
In conclusion, the acute dermal median lethal dose of the test substance is estimated to be in excess of 5000 mg/kg to male and female rats.
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