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EC number: 217-588-1 | CAS number: 1897-45-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 01 Feb 2000 to 07 Mar 2000
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 000
- Report date:
- 2000
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Version / remarks:
- 1998
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Chlorothalonil
- EC Number:
- 217-588-1
- EC Name:
- Chlorothalonil
- Cas Number:
- 1897-45-6
- Molecular formula:
- C8Cl4N2
- IUPAC Name:
- tetrachlorobenzene-1,3-dicarbonitrile
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Age at study initiation: young adult
- Weight at study initiation: males: 231 - 257 g; females: 153 - 199 g
- Housing: singly housed in a suspended stainless steel caging with mesh floors
- Diet: rodent chow
- Water: filtered tap water, ad libitum
- Acclimation period: 10 - 14 days
ENVIRONMENTAL CONDITIONS
- Temperature: 18 - 21 °C
- Photoperiod (hrs dark / hrs light): 12 hour light/dark cycle
IN-LIFE DATES: From: 01 Feb 2000 To: 07 Mar 2000
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- CMC (carboxymethyl cellulose)
- Remarks:
- 1% w/v aqueous
- Details on oral exposure:
- VEHICLE
- Concentration in vehicle: 30 %
MAXIMUM DOSE VOLUME APPLIED: 5000 mg/kg bw
- Doses:
- 5000 mg/kg bw
- No. of animals per sex per dose:
- 6 females and 5 males
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: observation daily; body weight prior to test substance administration (initial) and again on Days 7 and 14.
- Necropsy of survivors performed: yes (Day 14). Gross necropsies were performed on all animals. Tissues and organs of the thoracic and abdominal cavities were examined .
- Clinical signs including body weight: gross evaluation of skin and fur, eyes and mucous membranes, respiratory, circulatory, autonomic and central nervous systems, somatomotor activity and behaviour pattern. Particular attention was directed to observation of tremors, convulsions, salivation, diarrhea and coma
Results and discussion
- Preliminary study:
- Female - Range Finding Screen - 5000 mg/kg bw
The female survived and gained body weight during the 7-day observation period. There were no signs of gross toxicity, adverse pharmacologic effects or abnormal behaviour.
Effect levels
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Remarks on result:
- not determinable due to absence of adverse toxic effects
- Mortality:
- No mortality observed.
- Clinical signs:
- other: With the exception of ano-genital staining, soft faeces and/or diarrhea noted in all rats within 2 hours (in females) and 20 hours (in males) and Day 1 post-dosing, all animals appeared active and healthy over the 14-day observation period. There were no
- Gross pathology:
- No gross abnormalities were observed.
Any other information on results incl. tables
Table 1. Weight changes in animals treated with 5000 mg/kg bw test substance.
Animal |
Sex |
Body weight (g) |
||
Initial |
Day 7 |
Day 14 |
||
1 |
F |
162 |
200 |
233 |
2 |
F |
159 |
202 |
239 |
3 |
F |
170 |
207 |
246 |
4 |
F |
167 |
205 |
224 |
5 |
F |
153 |
194 |
209 |
6 |
M |
257 |
307 |
350 |
7 |
M |
232 |
318 |
353 |
8 |
M |
231 |
308 |
343 |
9 |
M |
242 |
325 |
366 |
10 |
M |
233 |
290 |
315 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the findings from the study performed in compliance with GLP and following the OPPTS 870.1100 guideline, the acute oral LD50 of the test substance is greater than 5000 mg/kg bw of the test substance in both the male and female rat.
- Executive summary:
An acute oral toxicity test was conducted in compliance with GLP and following the OPPTS 870.1100 guideline using rats to determine the potential for the test substance to produce toxicity via the oral route. Based on the results of this study, the acute oral LD50 of the test substance is greater than 5000 mg/kg of body weight in both the male and female rat. Initially, five thousand milligrams of the test substance per kilogram of body weight was administered to one healthy female rat by oral gavage. This animal was observed for 7 days. Due to the absence of mortality in this animal, a group of five females was administered the test substance at the same dose level. Since no females died, a group of 5 males was administered the test substance at 5000 mg/kg to assure that males were not the more sensitive sex. All animals were observed for mortality, signs of gross toxicity, and behavioural changes at least once daily for 14 days. Body weights were recorded prior to administration and again on Days 7 and 14 (termination). Necropsies were performed on all animals at terminal sacrifice.
In conclusion, the LD50 is greater than 5000 mg/kg bw for males and females.
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