Registration Dossier
Registration Dossier
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EC number: 222-158-1 | CAS number: 3373-59-9
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
- Most sensitive endpoint:
- sensitisation (skin)
Acute/short term exposure
- Hazard assessment conclusion:
- low hazard (no threshold derived)
- Most sensitive endpoint:
- sensitisation (skin)
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
L-TEE was found to be non-corrosive and non-irritating to skin and eye in tests performed on rabbits. Based on these result, L-TEE is not hazardous and is not classified according to CLP and DSD-DPD.
L-TME holds the same structure as L-TEE except that L-TME contains a methyl alkyl-side group to the ester bond and L-TEE an ethyl alkyl-side group. Both substances are characterized by a high water solubility, a low log Pow and low vapour pressure.
Based on the structural similarity and the similarity in physico-chemical properties determining skin irritation L-TME is considered not to be a skin irritant using the analogue approach to L-TEE. Further, due to the structural similarity to L-TEE (the L-Threonine part) and the differences in toxicokinetic properties (methanol and ethanol), the eye irritation of L-TME is described by the toxicity of methanol. Hence, L-TME is considered not to be an eye irritant based on the available testing data on methanol. Hence, L-TME is not classified according to CLP and DSD-DPD.
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
L-TME is only in indistrial settings, hence no exposure to the general population
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