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Diss Factsheets
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EC number: 856-663-9 | CAS number: 2400970-89-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_toxicological-information.png)
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 17 September 2020 thru 14 October 2020
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 020
- Report date:
- 2020
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 425 (Acute Oral Toxicity: Up-and-Down Procedure)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.1100 (Acute Oral Toxicity)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- up-and-down procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Carbamodithioic acid, bis(mixed 2-ethylhexyl and 2-methylbutyl and pentyl) derivs., antimony (3+) salts
- Molecular formula:
- C33H66N3S6Sb to C51H102N3S6Sb
- IUPAC Name:
- Carbamodithioic acid, bis(mixed 2-ethylhexyl and 2-methylbutyl and pentyl) derivs., antimony (3+) salts
- Test material form:
- liquid: viscous
Constituent 1
- Specific details on test material used for the study:
- PYSICAL DESCRIPTION: Highly viscous amber liquid.
PURITY: >99%
SOURCE OF TEST MATERIAL
- Source and lot/batch number of test material: WT05-19
- Expiration date of the lot/batch: not applicable
STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temp.
- Stability under storage conditions: stable for the duration of testing.
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Received from Charles River Laboratories on September 10, 2020
- Females (if applicable) nulliparous and non-pregnant: yes
- Age at study initiation: Young adult (8-9 weeks)
- Weight at study initiation: 175.1 - 208.1 grams
- Fasting period before study: Yes, overnight
- Housing: In caging which conforms to the size recommendations in the most recent Guide for the Care and Use of Laboratory Animals (Natl. Res. Council, 2011)
- Diet (e.g. ad libitum): Envigo Teklad Global 16% Protein Rodent Diet® #2016. The diet was available ad libitum, except during fasting
- Water (e.g. ad libitum): Filtered tap water was supplied ad libitum
- Acclimation period: 7-20 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21 - 23
- Humidity (%): 51 - 56
- Air changes (per hr): 12
- Photoperiod (hrs dark / hrs light): 12 hours
IN-LIFE DATES: From: To: September 17 - October 14, 2020
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- Limit Dose: 2000 mg/kg-bw
- No. of animals per sex per dose:
- 5
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: Days 0, 7, and 14
- Necropsy of survivors performed: yes
- Clinical signs including body weight: 30 min post-dosing, then each hour for several hours, then daily for 14 days
- Other examinations performed: clinical signs, body weight,organ weights, histopathology, other: No - Statistics:
- Statistical analysis was limited to the calculation of the mean density value for dosing.
Results and discussion
Effect levelsopen allclose all
- Key result
- Sex:
- female
- Dose descriptor:
- LD0
- Effect level:
- >= 2 000 mg/kg bw
- Based on:
- test mat.
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- No mortality observed throughout the study.
- Clinical signs:
- other: Normal; all animals active and healthy throughout the study.
- Gross pathology:
- Normal
Any other information on results incl. tables
Animal No. |
Sex |
Dose Level (mg/kg) |
Body Weight (g) |
Dose |
||
Initial |
Day 7 |
Day 14 |
mL |
|||
3101 |
F |
2000 |
175.1 |
205.4 |
227.2 |
0.72 |
3102 |
F |
185.3 |
200.6 |
205.1 |
0.76 |
|
3103 |
F |
199.1 |
216.8 |
244.8 |
0.81 |
|
3104 |
F |
200.7 |
230.6 |
244.2 |
0.82 |
|
3105 |
F |
208.1 |
241.7 |
256.7 |
0.85 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The Oral LD50 for the test substance is >2000 mg/kg-bw.
- Executive summary:
In an OECD 425 Guideline study conducted under GLP conditions using a limit dose of 2000 mg/kg-bw, no mortalities, changes in body-weight gain, clinical signs of toxicity, or abnormal findings in gross pathology were observed. Therefore, it can be concluded that the oral LD50 for the test substance is > 2000 mg/kg-bw.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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