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Reaction mass of lithium sodium hydrogen 4-amino-6-({5-[(5-chloro-2,6-difluoropyrimidin-4-yl)amino]-2-sulfonatophenyl}diazenyl)-5-hydroxy-3-[(4-{[2-(sulfonatooxy)ethyl]sulfonyl}phenyl)diazenyl]naphthalene-2,7-disulfonate and lithium sodium hydrogen 4-amino-6-({5-[(5-chloro-2,6-difluoropyrimidin-4-yl)amino]-2-sulfonatophenyl}diazenyl)-5-hydroxy-3-{[4-(vinylsulfonyl)phenyl]diazenyl}naphthalene-2,7-disulfonate
EC number: 941-533-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Additional information
A limit test was conducted to determine the acute toxicity of the test substance to Daphnia magna according to an internal SOP and with quality assurance review. In this test, 4 replicatesof 5 daphnids were exposed to the substance at a nominal concentration of 0, 300, 400 and 500 mg/L under static conditions for 24 h.Immobility was recorded at 24 h, alog with oxygen concentration, pH and temperature. The positive control potassium dichromate was tested in parallel at 0.75, 1.0, 1.25, 1.50, 1.75, 2.0, 3.0 and 5.0 mg/L. Under the test conditions, the 24 h EC0 of the test substance was >=500 mg/L (nominal) (Caspers, 1986).
A study was conducted to determine the acute toxicity of the test substance to the algae Desmodesmus subspicatus according to EU Method C.3, and an instruction for the performance of a modified algal growth inhibition test published by Memmert & Knoell (RCC Umweltchemie, August 1992), in compliance with GLP. Triplicate inocula of the algae were exposed to nominal concentrations of the test substance (0.4, 1.0, 2.3, 4.7, 10.3, 22.7 and 50 mg/L) for 72 h under static conditions. Quantification of the applied concentrations was carried out using HPLC. A second series (Part II) of test vessels treated in the same way as the controls (Part III), but placed below glass vessels containing the same range of concentrations of the test substance as described above, but without algae, was set up to distinguish between algistatic (indirect effect caused by light absorption) and algicidal (toxic) effects. The cell densities were measured at 24, 48 and 72 h. Inhibition of the algal population was measured as reduction in growth and growth rate, relative to control cultures grown under identical conditions. The measured concentrations of the test substance ranged from 102-117% of nominal values at 0 h, and from 73-113% of nominal values at 72 h. Under the conditions of the study, the 72 h EbC10 (biomass) and ErC10 (growth rate) for Desmodesmus subspicatus were determined to be 0.4 and 0.7 mg/L (nominal concentrations) respectively; the 72 h EbC50 and ErC50 were determined to be 2.9 and 6.8 mg/L (nominal concentrations) respectively; and the NOECs for biomass and growth rate were determined to be <0.4 and 0.4 mg/L (nominal concentration) respectively. A comparison of the results for the parameter "percentage inhibition of the growth rate" gained in Parts I and II of the study, results in differences exceeding 10% only at the highest test substance concentration (50 mg/L). At this concentration, the difference observed for this parameter was 14.7%. Due to the decreasing accuracy of the cell number determination procedure at very low levels, this difference was not considered as a difference between Parts I and II of the study. Therefore the inhibition of growth observed in this study was considered to be caused by light absorption only (Bruns, 2001).
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