Registration Dossier
Registration Dossier
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EC number: 237-998-4 | CAS number: 14154-42-8
Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2018
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 018
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 429 (Skin Sensitisation: Local Lymph Node Assay)
- GLP compliance:
- yes (incl. QA statement)
- Type of study:
- mouse local lymph node assay (LLNA)
Test material
- Reference substance name:
- Chloro[29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]aluminium
- EC Number:
- 237-998-4
- EC Name:
- Chloro[29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]aluminium
- Cas Number:
- 14154-42-8
- Molecular formula:
- C32H16AlClN8
- IUPAC Name:
- 31h-phthalocyaninato(2-)-n29,n39,n31,n32]-chloro[29(sp-5-12)-aluminu; chloro[29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]-,(SP-5-12)-Aluminum;CHLOROALUMINUM PHTHALOCYANINE;CHLORO(29H,31H-PHTHALOCYANINATO)ALUMINUM; CHLORO(PHTHALOCYANINATO)ALUMINIUM;ALUMINUM PHTHALOCYANINE CHLORIDE;PHTHALOCYANINE CHLOROALUMINUM; chloro[29H,31H-phthalocyaninato(2-)-N29,N30,N31,N32]aluminium
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
- Positive control results:
- weight (g) lymph nodes DPM SI
Positive Control 0.0642 10 9776 6.63
In vivo (LLNA)
Resultsopen allclose all
- Parameter:
- SI
- Value:
- 0.83
- Test group / Remarks:
- 10%
- Parameter:
- SI
- Value:
- 0.63
- Test group / Remarks:
- 25%
- Parameter:
- SI
- Value:
- 0.84
- Test group / Remarks:
- 50%
Any other information on results incl. tables
The Lymph node weight, DPM, SI, EC3 values.
|
Lymph node |
Number of |
|
|
|
|
|
weight (g) |
lymph nodes |
DPM |
SI |
EC3 (%) |
|
Control |
0.0285 |
10 |
1546 |
- |
-
|
|
Positive Control |
0.0642 |
10 |
9776 |
6.63* |
||
Chloro[29H,31H-phthlocyaninato(2-)-N29,N30,N31,N32]aluminium |
10% |
0.0296 |
10 |
1286 |
0.83 |
|
25% |
0.0261 |
10 |
982 |
0.63 |
||
50% |
0.0295 |
10 |
1292 |
0.84 |
||
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- he skin sensitizing potential of Chloro[29H,31H-phthlocyaninato(2-)-N29,N30,N31,N32] aluminium was assessed using the murine local lymph node assay.
Based on the results of this study, Chloro[29H,31H-phthlocyaninato(2-)-N29,N30,N31,N32] aluminium is not considered a skin sensitizer under the condition of this LLNA study.
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