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EC number: 225-713-6 | CAS number: 5025-82-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2017
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 017
- Report date:
- 2017
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- 3-acetylthiazolidine-4-carboxylic acid
- EC Number:
- 225-713-6
- EC Name:
- 3-acetylthiazolidine-4-carboxylic acid
- Cas Number:
- 5025-82-1
- Molecular formula:
- C6H9NO3S
- IUPAC Name:
- 3-acetylthiazolidine-4-carboxylic acid
Constituent 1
Test animals
- Species:
- rat
- Sex:
- female
Administration / exposure
- Route of administration:
- oral: drinking water
- Vehicle:
- olive oil
- Doses:
- The starting dose could be selected from the fixed dose levels of 5, 50, 300, and 2000 mg/kg body weight. Available information indicated that the test item is likely to be non-toxic with regard to acute toxicity. A limit dose of 2000 mg/kg body weight was used as a starting dose. One group of 3 females was dosed. Test item-related mortality was not observed during 24 hours and therefore, in a second step, another 3 females were treated at the same dose.
Results and discussion
Effect levels
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- >= 5 000 mg/kg bw
- Based on:
- other: Annex 2d Test Procedure with a Starting Dose of 2000 mg/kg body weight of OECD Guideline 423
- Mortality:
- No mortality was observed during the study.
- Clinical signs:
- other: No observed signs
- Gross pathology:
- All test animals were subjected to gross necropsy and the results were recorded for each animal.
Applicant's summary and conclusion
- Interpretation of results:
- Category 5 based on GHS criteria
- Conclusions:
- Based on Annex 2d Test Procedure with a Starting Dose of 2000 mg/kg body weight of OECD Guideline 423 it can be concluded that the test item 3-acetylthiazolidine-4-carboxylic acid is classified in Category 5/Unclassified with a LD50 cut off value equal to or greater than 5000 mg/kg body weight, after single oral administration to Wistar rats.
- Executive summary:
The purpose of the study was to evaluate the potential toxic effect of the test item3-acetylthiazolidine-4-carboxylic acidwhen administered as a single oral dose to Wistar rats.
The procedure according to OECD Guideline 423 Acute Toxic Class(ATC)method was used.
Alimit dose of 2000 mg/kg body weight was used as a starting dose.Two groups of 3 females was dosed. All 6 females survived the limit dose.The limit dose of 2000 mg/kg body weight did not cause death or evident signs of toxicity.The body weights of all animals increased during the study except 2 animals. Stagnation of the body weight in all animals except 1 animal was observed between the first and second week after administration. During necropsy, no macroscopic findings were observed.
The LD50of the test item3-acetylthiazolidine-4-carboxylic acidis greater than 2000 mg/kg body weight after single oral administration to Wistar rats.
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