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Diss Factsheets
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EC number: 204-854-7 | CAS number: 127-65-1
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Respiratory sensitisation
Administrative data
- Endpoint:
- respiratory sensitisation, other
- Type of information:
- other: collection of literature
Data source
Materials and methods
Results and discussion
Applicant's summary and conclusion
- Interpretation of results:
- other: Resp. Sens. Cat 1
- Remarks:
- in accordance with the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC).
- Conclusions:
- Based on the available data, Tosylchloramide sodium needs to be classified as respiratory sensitizer ( Resp. Sens. Cat 1,/ H334) in accordance with the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC).
- Executive summary:
Literature summary on Tosylchloramide sodium and sensitisation:
Tosylchloramide sodium is a known respiratory sensitiser in humans. As all known human chemical respiratory sensitisers elicit positive results in predictive animal tests for contact sensitisation, there is no use in performing such test for Tosylchloramide sodium, which is known to be able to cause IgE mediated occupational asthma (OA). The frequency of occurrence OA by Tosylchloramide sodium is unclear. At immunological investigations proof is found that Tosylchloramide sodium reacts with lysine-containing peptides. Suggesting that Tosylchloramide sodium acts as a hapten (Wass, U. and Belin, L., 1990). Specific IgE–antibodies are found which are directed to the p–toluenesulphonyl group.
In some people with skin reactions, a type IV allergic reaction to Chloramine–T could be seen upon patch testing. A large scale study (Hansen, K. S., 1983) shows that Tosylchloramide sodium rarely causes allergic contact eczema. Additionally Tosylchloramide sodium was tested in t he guinea pig maximization test (GPMT), local lymph node assay (LLNA), and the Buehler test for its potential to cause contact dermatitis and Chloramine-T tested positive in these predictive test for sensitization (Basketter, D.A., et al., 1996;Basketter, D.A., et al., 1999; Kimber, I., et al., 1994).
Based on the available data, Tosylchloramide sodium needs to be classified as respiratory sensitizer ( Resp. Sens. Cat 1,/ H334) in accordance with the criteria outlined in Annex I of the CLP Regulation (1272/2008/EC).
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