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EC number: 256-917-3 | CAS number: 51022-74-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Justification for type of information:
- In an aqueous environment, the iotroxic acid separates from the disodium salt immediately. Therefore, tests conducted with disodium salt in aqueous medium are representative for the toxicity of iotroxic azide.
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 1 000 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mortality
- Remarks:
- Immobilization
- Validity criteria fulfilled:
- yes
- Conclusions:
- No Daphnia was immoblized, neither in the test nor control solution.
The measured values are within the limit (<= 20% variation of the nominal) required by the OECD guideline 202.
The 48-hr EC50 of iotroxic acid, disodium salt to Daphnia magna is higher than 1000 mg/L (nominal). - Executive summary:
The 48 hr-acute toxicity of iotroxic acid, disodium salt to Daphnia magna Straus was studied under static conditions. Daphnids were exposed to a control containing no test substance, and iotroxic acid, disodium salt (purity 99.5%) at nominal concentration of 63, 125, 250, 500 and 1000 mg/L (mean concentrations of 60.1, 135.6, 242.7, 475,8 and 1011 mg/L) for 48 hr. Immobilization was observed daily.
The 48 – hr EC50 was higher than 1000 mg/L (nominal).
Based on the results of this study, iotroxic acid, disodium salt would not be classified as toxic to D. magna Straus in accordance with the classification system of the Regulation (EC) No 1272/2008 (CLP).
This study is classified as acceptable and satisfies the guideline requirements for an acute toxicity study with freshwater invertebrates.
Results Synopsis
Test Organism Age (e.g. 1st instar): < 24 hr
Test Type: Static
48 – hr EC50 > 1000 mg a.i./L, nominal
Endpoint(s) Effected: mortality, immobility
This information is used in a read-across approach in the assessment of the target substance.
Reference
Description of key information
In an acute immobilization test with Daphnia magna (STRAUS) according to OECD guideline 202, EC guideline Part 2 -Testing Methods, Part C.2 and GLP, the toxic effects of the test item to aquatic invertebrates were determined after 48 h exposure under static conditions.
The 48-h EC50was determined to be higher than 1000 mg/L (nominal). The nominal concentration was verified analytically.
Consequently, no hazard is identified.
Key value for chemical safety assessment
Additional information
This information is used in a read-across approach in the assessment of the target substance.
No data are available for iotroxic acid (target substance). Thus, iotroxic acid, disodium salt (source substance) is used to assess the aquatic toxicity of iotroxic acid in a read-across approach.
Data describing the acute aquatic toxicity of iotroxic acid is based on read-across from iotroxic acid, disodium salt. In aqueous solution disodium salt disassociates to iotroxic acid.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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