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Diss Factsheets
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EC number: 221-178-8 | CAS number: 3025-30-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: FHSA, 16 CFR 1500.3(c)(2)(i)
- GLP compliance:
- yes
- Test type:
- fixed dose procedure
- Limit test:
- yes
Test material
- Reference substance name:
- Ethyl (2E,4Z)-2,4-decadienoate
- EC Number:
- 221-178-8
- EC Name:
- Ethyl (2E,4Z)-2,4-decadienoate
- Cas Number:
- 3025-30-7
- Molecular formula:
- C12H20O2
- IUPAC Name:
- ethyl deca-2,4-dienoate
- Test material form:
- not specified
Constituent 1
- Specific details on test material used for the study:
- STABILITY AND STORAGE CONDITIONS OF TEST MATERIAL
- Storage condition of test material: room temperature and humidity
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Ace Animals
- Weight at study initiation: 249-291 g
- Fasting period before study: 16-20 hours before dosing
- Housing: 5 per cage, suspended wire mesh cages
- Diet (e.g. ad libitum): Purina Rat Chow ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: at least one week
ENVIRONMENTAL CONDITIONS
- Temperature (°C): controlled
- Humidity (%): controlled
- Photoperiod (hrs dark / hrs light): 12 hrs light/12 hrs dark
Administration / exposure
- Route of administration:
- oral: unspecified
- Vehicle:
- unchanged (no vehicle)
- Details on oral exposure:
- MAXIMUM DOSE VOLUME APPLIED: 5.0 g/kg
CLASS METHOD (if applicable)
- Rationale for the selection of the starting dose: If less than 5 rats at the 5.0 g/kg dose level die, then no further testing is needed. - Doses:
- 5.0 g/kg
- No. of animals per sex per dose:
- 10
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations and weighing: 3-4 hrs after exposure, and daily thereafter
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, mortality
Results and discussion
Effect levels
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 5 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- There was no mortalilty during the study.
- Clinical signs:
- other: See table below
- Gross pathology:
- Generally normal
- Other findings:
- - Histopathology: Animal #4 had hydronephrosis of the right kidney
Any other information on results incl. tables
Clinical Signs
Physical Sign | Maximum Number of Animals showing Sign at One Observation Period |
Chromorhinorrhea | 4 |
Ptosis | 3 |
Chromodacryorrhea | 2 |
Lethargy | 1 |
Yellow Nasal Discharge | 1 |
Anogenital Area Stained Brown | 2 |
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The oral LD50 is > 5 g/kg in rats.
- Executive summary:
The oral toxicity of ethyl decadienoate was tested in 10 rats. The 10 male rats were given doses of 5 g/kg of the test substance. They were then monitored for 14 days. No animals died during the study. Some minor clinical signs were noted, and only one abnormality was noted during the necropsies. The acute oral LD50 is therefore > 5 g/kg.
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