Registration Dossier
Registration Dossier
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EC number: 278-562-3 | CAS number: 76836-02-7
Water solubility
Administrative data
Link to relevant study record(s)
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 November 2017 to 14 December 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.6 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7840 (Water Solubility)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Key result
- Water solubility:
- 855 g/L
- Conc. based on:
- test mat.
- Temp.:
- 19.8 °C
- pH:
- >= 9.4 - <= 9.7
- Remarks on result:
- other: mean value of the 48- and 72-hour measurements
- Details on results:
- An increment in concentration was observed between the 24, 48 and 72- hour measurements (maximum difference > 15%). Based on this, the water solubility of the test item was given as the mean value of the 48- and 72-hour measurements.
A small response was observed at the retention time of the test item. The maximum contribution of the area to the sample with the lowest analysed concentration is 0.0000015%. - Conclusions:
- This study validly assessed the solubility in water according to the specificied guidelines.The water solubility of the test item at 19.8°C was 855 g/L.
Reference
| Stirring time [hours] | Analyzed concentration [g/L] | pH |
| 24 | 750 | 9.8 |
| 48 | 803 | 9.4 |
| 72 | 906 | 9.7 |
Description of key information
The flask method was applied for the determination of the water solubility of 1,4 piperazinediethanesulfonic acid disodium salt.
The water solubility of the test item at 19.8°C was 855 g/L.
The pH of the aqueous samples was 9.8, 9.4, and 9.7 after stirring for 24, 48, and 72 hours respectively
Key value for chemical safety assessment
- Water solubility:
- 855 g/L
- at the temperature of:
- 19.8 °C
Additional information
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