Registration Dossier
Registration Dossier
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EC number: 278-562-3 | CAS number: 76836-02-7
Partition coefficient
Administrative data
Link to relevant study record(s)
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 02 November 2017 to 14 December 2017
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- EU Method A.8 (Partition Coefficient - Shake Flask Method)
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 107 (Partition Coefficient (n-octanol / water), Shake Flask Method)
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 830.7550 (Partition Coefficient, n-octanol / H2O, Shake Flask Method)
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- flask method
- Partition coefficient type:
- octanol-water
- Analytical method:
- other: UPLC-MS
- Key result
- Type:
- Pow
- Partition coefficient:
- <= 0
- Temp.:
- 20 °C
- Remarks on result:
- other: pH not reported
- Key result
- Type:
- log Pow
- Partition coefficient:
- <= -6
- Temp.:
- 20 °C
- Remarks on result:
- other: pH not reported
- Details on results:
- The maximum difference of the concentrations determined in the 24, 48 and 72 hour test samples was >15%. Since furthermore three centrifugation steps proved not sufficient to remove all undissolved test item (solubility was 0.619 mg/L after 3 centrifugation steps and 0.392 mg/L after 4 centrifugation steps) and more accurate results cannot be obtained, it was decided to report the n-octanol solubility of the test item as a ≤ value (i.e. ≤ 0.0008 g/L). The Pow, calculated as the quotient of the n-octanol- and water solubility, is ≤ 9.4 10-7. It corresponds with a log Pow value of ≤ -6.0. No test item was detected in the pretreated sample from the blank n-octanol mixture.
- Conclusions:
- The partition coefficient of the test item has been determined to be ≤ 9.4 x 10^-7, log Pow value of ≤ -6.0.
Reference
| Stirring time [hours] | Analyzed concentration [g/L] | |
| 24 | 0.000619 | |
| 48 | 0.000778 | |
| 72 | 0.000633 |
Description of key information
The estimation method was applied for the determination of the partition coefficient (Pow) of 1,4 piperazinediethanesulfonic acid disodium salt.
The Pow value of the test item at 20°C was ≤ 9.4 x 10^-7 .
It corresponds with a log Pow value of ≤ -6.0.
Key value for chemical safety assessment
- Log Kow (Log Pow):
- -6
- at the temperature of:
- 20 °C
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
