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EC number: 947-572-6 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin irritation/corrosion
In a study already performed in the 1960s the undiluted test substance was severely irritant to the rabbit´s skin after a 20-hours contact period, as evidenced by skin inflammation with scabs and scales formation which were reversible at the end of the 14-days observation period.
In a study performed according the requirement of "Department of Transportation" (§ 173.1200, Federal Register) it was verified 1979 that the undiluted test substance was irritant but not corrosive to the rabbit´s skin after a 4-hours contact period.
Eye irritation
In a study already performed in the 1960s the undiluted test substance was irritant to the rabbit´s eye, as evidenced by reddening and swelling of the conjunctivae and diffuse areas of corneal opacity. All effects were reversible within one week after instillation of the test substance.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study report which meets basic scientific principles
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The skin irritation study in experimental animals was already performed in the 1960s. Therefore it is not conducted in accordance with the rules of Good Laboratory Practice (GLP) and internationally-agreed guidelines (e.g. OECD guideline No. 404), but using good scientific practices at that time.
BASF-Test, see details in remarks on material and methods. - GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or test system and environmental conditions:
- no information available
- Type of coverage:
- open
- Preparation of test site:
- not specified
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): no data available - Duration of treatment / exposure:
- 1 min., 5 min., 15 min. and 20 hour(s)
- Observation period:
- 14 days
- Number of animals:
- no data available
- Details on study design:
- The backs and ears of very susceptible white rabbits were treated with undiluted test material. After several exposure times the application side was examined after washing (after 1, 5 and 15 minutes exposure; no washing after exposure during 20 hours). The effects observed were described qualitatively.
REMOVAL OF TEST SUBSTANCE
- Washing (if done): with Lutrol concentrated and afterwards with Lutrol diluted to 50 % with water.
- Scoring system: no data, results are described qualitatively
- Examination time points: at the end of exposure - Irritation parameter:
- other: qualitative description of effects
- Basis:
- animal:
- Time point:
- other: after 1, 5 and 15 minutes
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- other: qualitative description of effects
- Basis:
- animal:
- Time point:
- other: 20 hours and 14 days after the end of exposure
- Reversibility:
- other: fully reversible within 14 days.
- Remarks on result:
- other: inflammation followed by degeneration involving only the upper layers of the skin
- Interpretation of results:
- other: irritant
- Executive summary:
In a study already performed in the 1960s the undiluted test substance was severely irritant to the rabbit´s skin after a 20-hours contact period, as evidenced by skin inflammation with scabs and scales formation which were reversible at the end of the 14-days observation period.
- Endpoint:
- skin irritation / corrosion, other
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study report which meets basic scientific principles
- Qualifier:
- according to guideline
- Guideline:
- other: Department of Transportation, § 173.1200, Federal Register
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS- Source: Gaukler
- Mean weight at study initiation: ca. 3 kg
- Housing: individual
- Diet: Sniff K ad libitum
- Water: ad libitum - Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.5 mL - Duration of treatment / exposure:
- 4 hour(s)
- Observation period:
- 8 days
- Number of animals:
- 5 males, 1 female
- Details on study design:
- TEST SITE-Area of exposure: 2 x 2 cm, cotton cloth soaked with the test material and held in place using adhesive tape. After a 4-hours exposure the patches were removed and the test substance was removed from the application site by washing with Lutrol concentrated and Lutrol diluted to 50 %. The resulting reactions were evaluated at the end of the exposure and readings were again made 24, 48 hours and 8 days.
- Irritation parameter:
- erythema score
- Remarks:
- original BASF grading
- Basis:
- animal: 1-6
- Time point:
- other: after removal of the patch
- Score:
- 2
- Max. score:
- 4
- Irritation parameter:
- edema score
- Remarks:
- original BASF grading
- Basis:
- animal: 1; 3-6
- Time point:
- other: after removal of the patch
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Remarks:
- original BASF grading
- Basis:
- animal #2
- Time point:
- other: after removal of the patch
- Score:
- 2
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Remarks:
- original BASF grading
- Basis:
- animal: 1-6
- Time point:
- 24/48 h
- Score:
- 3
- Max. score:
- 4
- Remarks on result:
- other: extended beyond the application area (5/6 rabbits)
- Irritation parameter:
- edema score
- Remarks:
- original BASF grading
- Basis:
- animal: 1-6
- Time point:
- 24/48 h
- Score:
- 4
- Max. score:
- 4
- Remarks on result:
- other: extended beyond the application area (3/6 rabbits at 48h)
- Irritation parameter:
- erythema score
- Remarks:
- original BASF grading
- Basis:
- animal #6
- Time point:
- other: 8d
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Remarks:
- original BASF grading
- Basis:
- animal #6
- Time point:
- other: 8d
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- erythema score
- Remarks:
- original BASF grading
- Basis:
- animal: 2-4
- Time point:
- other: 8d
- Score:
- 2
- Max. score:
- 4
- Remarks on result:
- other: with scaling extended beyond the application area
- Irritation parameter:
- erythema score
- Remarks:
- original BASF grading
- Basis:
- animal #5
- Time point:
- other: 8d
- Score:
- 3
- Max. score:
- 4
- Remarks on result:
- other: with scaling extended beyond the application area
- Irritation parameter:
- erythema score
- Remarks:
- original BASF grading
- Basis:
- animal #1
- Time point:
- other: 8d
- Score:
- 1
- Max. score:
- 4
- Remarks on result:
- other: with scaling
- Irritation parameter:
- edema score
- Remarks:
- original BASF grading
- Basis:
- animal: 1; 2; 6
- Time point:
- other: 8d
- Score:
- 0
- Max. score:
- 4
- Irritation parameter:
- edema score
- Remarks:
- original BASF grading
- Basis:
- animal: 4; 5
- Time point:
- other: 8d
- Score:
- 2
- Max. score:
- 4
- Irritation parameter:
- edema score
- Remarks:
- original BASF grading
- Basis:
- animal #3
- Time point:
- other: 8d
- Score:
- 1
- Max. score:
- 4
- Other effects:
- No systemic adverse effects were observed.
- Interpretation of results:
- other: not corrosive
- Executive summary:
In a study performed according the requirement of "Department of Transportation" (§ 173.1200, Federal Register) the undiluted test substance was not corrosive to the rabbit´s skin after a 4-hours contact period, as evidenced by erythema and oedema formation which exacerbated within 48 hours after removal of the patch and were fully reversible in only 1/6 rabbits. Also scaling but no necroses involving all layers of skin were observed at the end of 8-day observation period. Therefore the test substance should be considered an irritant.
Referenceopen allclose all
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Well documented study report which meets basic scientific principles
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- The eye irritation study in experimental animals was already performed in the 1960s. Therefore it is not conducted in accordance with the rules of Good Laboratory Practice (GLP) and internationally-agreed guidelines (e.g. OECD guideline No. 405), but using good scientific practices at that time.
BASF-Test, see details in remarks on material and methods. - GLP compliance:
- no
- Species:
- rabbit
- Strain:
- not specified
- Details on test animals or tissues and environmental conditions:
- no information available.
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: The adjacent eye treated with 0.9 % NaCl (saline) served as a control.
- Duration of treatment / exposure:
- 30 sec exposure
- Observation period (in vivo):
- 1 week post-instillation
- Number of animals or in vitro replicates:
- no information available
- Details on study design:
- One drop of undiluted test substance was instilled into the conjunctival sac of the rabbit eye and gently spaced it out evenly onto the ocular surface. Following 10 minutes, 1, 3 and 24 hours exposure period these eyes were evaluated. Narrative description of the degree and nature of irritation or corrosion observed.
- Irritation parameter:
- other: narrative description of the degree and nature of effects observed
- Basis:
- other: no data available
- Time point:
- other: 10 min, 1, 3 and 24 h
- Score:
- 0
- Remarks on result:
- other: Significant irritation (redness and swelling of conjunctivae, cornea with diffuse areas of opacity)
- Irritation parameter:
- other: narrative description of the degree and nature of effects observed
- Basis:
- other: no data available
- Time point:
- other: over the course of one week
- Score:
- 0
- Reversibility:
- fully reversible
- Interpretation of results:
- other: irritant
- Executive summary:
In a study already performed in the 1960s the undiluted test substance was irritant to the rabbit´s eye, as evidenced by reddening and swelling of the conjunctivae and diffuse areas of corneal opacity. All effects were reversible within one week after instillation of the test substance.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
On the basis of the available information a classification according to Regulation (EC) No 1272/2008, Annex I, is warranted:
Skin Irrit. Cat. 2 H315
Eye Irrit. Cat. 2 H319
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