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Diss Factsheets
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EC number: 243-855-7 | CAS number: 20506-24-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Skin sensitisation
Administrative data
- Endpoint:
- skin sensitisation: in vivo (non-LLNA)
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1979-11-05 to 1980-01-23
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- study well documented, meets generally accepted scientific principles, acceptable for assessment
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 979
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: "Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics" (1959), the US Association of Food and Drug Officials (AFDO)
- Deviations:
- not specified
- GLP compliance:
- no
- Type of study:
- Freund's complete adjuvant test
- Justification for non-LLNA method:
- No LLN study has been performed since valid data obtain in guinea pigs are available.
Test material
- Reference substance name:
- Cobaltate(1-), bis[2-(3-chlorophenyl)-2,4-dihydro-4-[[2-hydroxy-5-(methylsulfonyl)phenyl]azo]-5-methyl-3H-pyrazol-3-onato(2-)]-, hydrogen, compd. with [1R-(1α,4aβ,10aα)]-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine (1:1)
- EC Number:
- 243-855-7
- EC Name:
- Cobaltate(1-), bis[2-(3-chlorophenyl)-2,4-dihydro-4-[[2-hydroxy-5-(methylsulfonyl)phenyl]azo]-5-methyl-3H-pyrazol-3-onato(2-)]-, hydrogen, compd. with [1R-(1α,4aβ,10aα)]-1,2,3,4,4a,9,10,10a-octahydro-1,4a-dimethyl-7-(1-methylethyl)-1-phenanthrenemethanamine (1:1)
- Cas Number:
- 20506-24-5
- Molecular formula:
- C34 H26 Cl2 Co N8 O8 S2 . C20 H31 N . H
- IUPAC Name:
- (2Z,2'Z)-7,7'-bis(3-chlorophenyl)-15,15'-dimethanesulfonyl-5,5'-dimethyl-9,9',11,11'-tetraoxa-2,2',3,3',6,6',7,7'-octaaza-10-cobalta-10,10'-spirobi[tricyclo[10.4.0.0⁴,⁸]hexadecane]-1(12),1'(12'),2,2',4(8),4'(8'),5,5',13,13',15,15'-dodecaen-10-uide; [1,4a-dimethyl-7-(propan-2-yl)-1,2,3,4,4a,4b,8a,9,10,10a-decahydrophenanthren-1-yl]methanaminium
Constituent 1
In vivo test system
Test animals
- Species:
- guinea pig
- Strain:
- Pirbright-Hartley
- Sex:
- male/female
- Details on test animals and environmental conditions:
- TEST ANIMALS
- Source: Bantin and Kingman Ltd. Grimston, Hull, England
- Weight at study initiation: 385 - 404 g (f); 395 - 401 g (m)
- Housing: individually in macrolon cages (Type 3)
- Diet: ad libitum, standard diet (NAFAG, No. 830, Gossau SG)
- Water: ad libitum
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 22±2
- Humidity (%): 55±10
- Photoperiod (hrs dark / hrs light): 14/10
Study design: in vivo (non-LLNA)
Induction
- Route:
- epicutaneous, open
- Vehicle:
- propylene glycol
- Concentration / amount:
- Induction: 0.1 % in physiological saline (during 2nd and 3rd week the test substance was solved in a 1:1 mixture of normal vehicle and Freund complete adjuvant)
Challenge
- Route:
- intradermal and epicutaneous
- Vehicle:
- propylene glycol
- Concentration / amount:
- epicutaneous: 0.1 % in physiological saline
intradermal: 30 % in vaseline
- No. of animals per dose:
- 20 (10/sex)
- Details on study design:
- MAIN STUDY
A. INDUCTION EXPOSURE
- No. of exposures: 10
- Test group: Injection of a freshly prepared suspension of the test substance
- Control group: Injection of the vehicle (propylene glycol)
- Site: right flank and the back
- Frequency of applications: every second day (except weekends)
- Duration: 3 weeks
- Concentrations: 0.1 %
B. CHALLENGE EXPOSURE (INTRADERMAL)
- No. of exposures: 1
- Day(s) after induction: 14 days
- Test group: Injection of a freshly prepared suspension of the test substance
- Control group: Injection of a freshly prepared suspension of the test substance
- Site: left flank and the back
- Concentrations: 0.1 %
- Evaluation (hr after challenge): 24 hours
C. CHALLENGE EXPOSURE (EPICUTANEOUS)
- No. of exposures: 1
- Days after induction: 24 days
- Test group: Epicutaneous application of the test substance in vaseline.
- Control group: Epicutaneous application of the test substance in vaseline.
- Site: left flank and the back
- Concentrations: 30 %
- Evaluation (hr after challenge): 24 hours - Challenge controls:
- Not available
- Positive control substance(s):
- no
Results and discussion
In vivo (non-LLNA)
Resultsopen allclose all
- Reading:
- other: Reading after intradermal exposure
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 0.1 %
- No. with + reactions:
- 4
- Total no. in group:
- 20
- Reading:
- other: Reading after intradermal exposure
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 0.1 %
- No. with + reactions:
- 17
- Total no. in group:
- 20
- Reading:
- other: Reading after epicutaneous occlusive exposure
- Hours after challenge:
- 24
- Group:
- negative control
- Dose level:
- 30 % in vaseline
- No. with + reactions:
- 0
- Total no. in group:
- 20
- Reading:
- other: Reading after epicutaneous occlusive exposure
- Hours after challenge:
- 24
- Group:
- test chemical
- Dose level:
- 30 % in vaseline
- No. with + reactions:
- 0
- Total no. in group:
- 20
Any other information on results incl. tables
Under the experimental conditions employed, significant differences between the test group and the vehicle treated controls were only seen after intradermal challenge application i.e. when the skin barrier was intentionally by-passed. No difference between the test and the control group was seen after epidermal challenge application. The negative results upon epidermal challenge demonstrate that, in artificially sensitized guinea-pigs, exposure
of the intact skin to the test compound does not provoke contact dermatitis.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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