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Diss Factsheets
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EC number: 480-060-6 | CAS number: 24065-33-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
- Endpoint:
- basic toxicokinetics, other
- Remarks:
- expert judgement
- Type of information:
- other: expert judgement
- Adequacy of study:
- other information
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to same study
- Objective of study:
- absorption
- Qualifier:
- no guideline followed
- Principles of method if other than guideline:
- Toxicokinetic statement based on available physico-chemical and toxicological data according to REACH Guidance R.7
- GLP compliance:
- no
- Details on absorption:
- The toxicokinetics of 5-Chlorthiophen-2-carbonsäure are based on the studies performed within the process of registration of a new chemical under the Chemicals Act, Base Set. Experimental toxicokinetic studies have not been performed. The physico-chemical characteristics of 5-Chlorthiophen-2-carbonsäure (readily soluble in water (1.01 g/L at 20 °C), log POW of 1.95) and the molecular mass of 162.6 g/mol are in a range suggestive of absorption from the gastro-intestinal tract subsequent to oral ingestion. This assumption is confirmed by the data on acute and subacute oral toxicity. The findings of the subacute oral toxicity study indicate systemic availability of the test substance. The NOAEL of this study was established at 50 mg/kg body weight/day in male and female animals. The onset of growth retardation early during the study (after the first treatment with the test substance) suggests rapid absorption from the GI tract.
Water solubility, n-octanol/water partition coefficient and molecular weight of 5-Chlorthiophen-2-carbonsäure are in ranges which favor dermal absorption. Therefore, absorption through the skin may be assumed a route of exposure. However, in a study assessing the acute dermal toxicity of 5-Chlorthiophen-2-carbonsäure to rats a dose of 2000 mg/kg body weight was tolerated by male and female animals without mortalities, clinical signs, effects on body weight development and gross pathological findings. In acute skin and eye irritation studies in rabbits no systemic intolerance reactions have been observed and no sensitizing effect has been identified in the Local Lymph Node Assay. Based on the results of the in vitro genotoxicity tests it is concluded that DNA-reactive metabolites of 5-Chlorthiophen-2-carbonsäure will most probably not be generated in mammals in the course of hepatic biotransformation. - Conclusions:
- The test item is considered to be readily intestinally absorbed. Dermal absorption seems to be reduced in comparison to oral absorption based on the results from the acute dermal toxicity and skin and eye irritation studies.
Reference
Description of key information
The test item is considered to be readily intestinally absorbed. Dermal absorption seems to be reduced in comparison to oral absorption based on the results from the acute dermal toxicity and skin and eye irritation studies.
Key value for chemical safety assessment
- Bioaccumulation potential:
- no bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 10
- Absorption rate - inhalation (%):
- 100
Additional information
The toxicokinetics of 5-Chlorthiophen-2-carbonsäure are based on the studies performed within the process of registration of a new chemical under the Chemicals Act, Base Set. Experimental toxicokinetic studies have not been performed. The physico-chemical characteristics of 5-Chlorthiophen-2-carbonsäure (readily soluble in water (1.01 g/L at 20 °C), log POW of 1.95) and the molecular mass of 162.6 g/mol are in a range suggestive of absorption from the gastro-intestinal tract subsequent to oral ingestion. This assumption is confirmed by the data on acute and subacute oral toxicity. The findings of the subacute oral toxicity study indicate systemic availability of the test substance. The NOAEL of this study was established at 50 mg/kg body weight/day in male and female animals. The onset of growth retardation early during the study (after the first treatment with the test substance) suggests rapid absorption from the GI tract.
Water solubility, n-octanol/water partition coefficient and molecular weight of 5-Chlorthiophen-2-carbonsäure are in ranges which favor dermal absorption. Therefore, absorption through the skin may be assumed a route of exposure. However, in a study assessing the acute dermal toxicity of 5-Chlorthiophen-2-carbonsäure to rats a dose of 2000 mg/kg body weight was tolerated by male and female animals without mortalities, clinical signs, effects on body weight development and gross pathological findings. In acute skin and eye irritation studies in rabbits no systemic intolerance reactions have been observed and no sensitizing effect has been identified in the Local Lymph Node Assay. Based on the results of the in vitro genotoxicity tests it is concluded that DNA-reactive metabolites of 5-Chlorthiophen-2-carbonsäure will most probably not be generated in mammals in the course of hepatic biotransformation.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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