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EC number: 231-832-4 | CAS number: 7758-09-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Skin Irritation
Based on the available results and applying the weight of evidence approach, the test chemical can be considered to be not irritating to skin. Hence, it can be classified under the category "Not Classified" as per CLP Regulation.
Eye Irritation
Based on the available results and applying the weight of evidence approach, the test chemical can be considered to be not irritating to eyes. Hence, it can be classified under the category "Not Classified" as per CLP Regulation.
Key value for chemical safety assessment
Skin irritation / corrosion
Link to relevant study records
- Endpoint:
- skin irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Weight of evidence approach based on various test chemicals
- Justification for type of information:
- Weight of evidence approach based on various test chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: Weight of evidence approach based on various test chemicals
- Principles of method if other than guideline:
- Weight of evidence approach based on various test chemicals
- GLP compliance:
- not specified
- Species:
- other: 2. rabbits; 3. guinea pigs
- Strain:
- other: 2. New Zealand White
- Details on test animals or test system and environmental conditions:
- 2. Sex: male
- Type of coverage:
- other: 2. semi-occlusive; 3. occlusive
- Preparation of test site:
- other: 2. shaved;
- Vehicle:
- other: 2. undiluted; 3. distilled water
- Controls:
- not specified
- Amount / concentration applied:
- 2. 500 mg
3. 95% - Duration of treatment / exposure:
- 2. 4 hours
3. 24 hours - Observation period:
- 2.one hour, one, two and three days after removal of the chemical
3. 3 weeks - Number of animals:
- 2. 6 male rabbits
3. 10 guinea pigs - Details on study design:
- 2,3. no details available
- Irritation parameter:
- overall irritation score
- Remarks:
- Study 2
- Basis:
- mean
- Time point:
- other: 1 hour
- Reversibility:
- fully reversible within: 1 day
- Remarks on result:
- no indication of irritation
- Irritation parameter:
- overall irritation score
- Remarks:
- Study 3
- Basis:
- mean
- Time point:
- other: 3 weeks
- Reversibility:
- not specified
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- 2. Some slight irritation was observed one hour after removal of the substance, but all signs had disappeared by the one day observation
3. The chemical did not cause skin irritation in guinea pigs. - Interpretation of results:
- other: not irritating
- Conclusions:
- Based on the available results and applying the weight of evidence approach, the test chemical can be considered to be not irritating to skin. Hence, it can be classified under the category "Not Classified" as per CLP Regulation.
- Executive summary:
Various studies have been reviewed to evaluate the dermal irritation potential of the test chemical. The results are as mentioned below:
A dermal irritation study was performed to assess the dermal irritation potential of the test chemical in rabbits. Approximately 500 mg of the test chemical was applied to the shaved backs of 6 male New Zealand White rabbits and covered with a semi-occlusive dressing for four hours. The animals were examined one hour, one, two and three days after removal of the chemical. Some slight irritation was observed one hour after removal of the test chemical, but all signs had disappeared by the one day observation. Hence, the test chemical can be considered to be not irritating to skin.
This result is supported by another skin irritation study was conducted on guinea pigs to determine the skin irritating effects of the test chemical.The test substance (moistened with distilled water) was applied for 24 h, under occlusive patch, to the skin at a concentration of 95% over a period of 3 weeks.Since the chemical did not induce any skin lesions, the test chemical was considered to be not irritating to the skin of treated guinea pigs.
Based on the available results and applying the weight of evidence approach, the test chemical can be considered to be not irritating to skin. Hence, it can be classified under the category "Not Classified" as per CLP Regulation.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed (not irritating)
Eye irritation
Link to relevant study records
- Endpoint:
- eye irritation: in vivo
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- weight of evidence
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- data from handbook or collection of data
- Remarks:
- Weight of evidence approach based on various test chemicals
- Justification for type of information:
- Weight of evidence approach based on various test chemicals
- Reason / purpose for cross-reference:
- read-across source
- Reason / purpose for cross-reference:
- read-across source
- Qualifier:
- according to guideline
- Guideline:
- other: As mentioned below
- Principles of method if other than guideline:
- A modified Draize ocular irritation test was conducted to evaluate the irritancy of test chemical to the rabbit eye.
- GLP compliance:
- no
- Species:
- rabbit
- Strain:
- other: 2. not specified 3.New Zealand White
- Details on test animals or tissues and environmental conditions:
- No data
- Vehicle:
- other: 2. Not specified 3. unchanged (no vehicle)
- Controls:
- yes, concurrent no treatment
- not specified
- Amount / concentration applied:
- 2) 1, 5, and 10%
3) 100% (0.1ml) - Duration of treatment / exposure:
- 2) 24 hours
3) Single application - Observation period (in vivo):
- 2) Eyes were scored at 1, 2, and 24 h and daily thereafter until all irritation had disappeared.
3) 7 days - Number of animals or in vitro replicates:
- 2) 3 rabbits
3) 6 male rabbits - Details on study design:
- 2. No data
3. REMOVAL OF TEST SUBSTANCE
- Washing (if done): Not rinsed - Irritation parameter:
- overall irritation score
- Remarks:
- 2.
- Basis:
- mean
- Time point:
- 24 h
- Score:
- 0
- Max. score:
- 110
- Remarks on result:
- other: No ocular irritation was observed in treated rabbits.
- Irritation parameter:
- overall irritation score
- Remarks:
- 3.
- Basis:
- mean
- Time point:
- 7 d
- Remarks on result:
- no indication of irritation
- Irritant / corrosive response data:
- No data
- Other effects:
- 2. No data
3. Mild or moderate conjunctival redness and discharge and moderate or severe chemosis were observed in all animals at 1 h post instillation. At day 4, chemosis and discharge were fully reversible in all animals. The test substance did not induce substantial corneal opacity or iritis. The study was terminated before all ocular reactions were completely reversed. - Interpretation of results:
- other: Not irritating
- Conclusions:
- The test material was considered to be not irritating to the eyes of treated rabbits.
- Executive summary:
Various studies have been reviewed to evaluate the ocular irritation potential of the test chemical. The results are mentioned below:
A modified Draize ocular irritation test was conducted to evaluate the irritancy of test chemical to the three rabbit eye.The chemical was instilled into the eyes of each rabbit at a dose of 1, 5, and 10% and eyes were scored at 1, 2, and 24 h and daily thereafter until all irritation had disappeared.The test chemical had an ocular irritation index of 0 at all concentrations (at 24 h) Therefore, the test chemical was considered to be not irritating to the rabbits’ eyes.
An ocular irritation study of test chemical was conducted on 6 male New Zealand white rabbits to assess its adverse effects on treated rabbits. The undiluted (0.1 ml) test substance was instilled into the eyes of each rabbit. The eyes were not rinsed and untreated eyes served as controls. Instillation of the test substance was followed by a 7-day observation period. Mild or moderate conjunctival redness and discharge and moderate or severe chemosis were observed in all animals at 1 h post instillation. At day 4, chemosis and discharge were fully reversible in all animals. The test substance did not induce substantial corneal opacity or iritis. The study was terminated before all ocular reactions were completely reversed. However, the authors noted observations relating to the healing process indicated that the complete reversibility of ocular reactions was likely.Therefore the test chemical was considered to be not irritating to the eyes of treated New Zealand white rabbits.
Based on the available results and applying the weight of evidence approach, the test chemical can be considered to be not irritating to eyes. Hence, the test chemical cannot be classified as per CLP Regulation.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (irritating)
Respiratory irritation
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Skin irritation
Various studies have been reviewed to evaluate the dermal irritation potential of the test chemical. The results are as mentioned below:
A dermal irritation study was performed to assess the dermal irritation potential of the test chemical in rabbits. Approximately 500 mg of the test chemical was applied to the shaved backs of 6 male New Zealand White rabbits and covered with a semi-occlusive dressing for four hours. The animals were examined one hour, one, two and three days after removal of the chemical. Some slight irritation was observed one hour after removal of the test chemical, but all signs had disappeared by the one day observation. Hence, the test chemical can be considered to be not irritating to skin.
This result is supported by another skin irritation study was conducted on guinea pigs to determine the skin irritating effects of the test chemical.The test substance (moistened with distilled water) was applied for 24 h, under occlusive patch, to the skin at a concentration of 95% over a period of 3 weeks.Since the chemical did not induce any skin lesions, the test chemical was considered to be not irritating to the skin of treated guinea pigs.
Based on the available results and applying the weight of evidence approach, the test chemical can be considered to be not irritating to skin. Hence, it can be classified under the category "Not Classified" as per CLP Regulation.
Eye Irritation
Various studies have been reviewed to evaluate the ocular irritation potential of the test chemical. The results are mentioned below:
A modified Draize ocular irritation test was conducted to evaluate the irritancy of test chemical to the three rabbit eye.The chemical was instilled into the eyes of each rabbit at a dose of 1, 5, and 10% and eyes were scored at 1, 2, and 24 h and daily thereafter until all irritation had disappeared.The test chemical had an ocular irritation index of 0 at all concentrations (at 24 h) Therefore, the test chemical was considered to be not irritating to the rabbits’ eyes.
An ocular irritation study of test chemical was conducted on 6 male New Zealand white rabbits to assess its adverse effects on treated rabbits. The undiluted (0.1 ml) test substance was instilled into the eyes of each rabbit. The eyes were not rinsed and untreated eyes served as controls. Instillation of the test substance was followed by a 7-day observation period. Mild or moderate conjunctival redness and discharge and moderate or severe chemosis were observed in all animals at 1 h post instillation. At day 4, chemosis and discharge were fully reversible in all animals. The test substance did not induce substantial corneal opacity or iritis. The study was terminated before all ocular reactions were completely reversed. However, the authors noted observations relating to the healing process indicated that the complete reversibility of ocular reactions was likely.Therefore the test chemical was considered to be not irritating to the eyes of treated New Zealand white rabbits.
Based on the available results and applying the weight of evidence approach, the test chemical can be considered to be not irritating to eyes. Hence, the test chemical cannot be classified as per CLP Regulation.
Justification for classification or non-classification
Based on the available results and applying the weight of evidence approach, the test chemical can be considered to be not irritating to skin and eye. Hence, it can be classified under the category "Not Classified" as per CLP Regulation.
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