Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 251-132-2 | CAS number: 32634-68-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
![](https://echa.europa.eu/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/print_ecotoxicological-information.png)
Endpoint summary
Administrative data
Description of key information
Short term toxicity to aquatic invertebrate:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the short term toxicity of aquatic invertebrate of the test chemical 2,3-bis[(4-methylbenzoyl)oxy]succinic acid (32634 -68 -7).The studies are as mentioned below:
1. The test material was used to evaluate the short term toxicity test on Daphnia magna Straus .A stock of individually reared daphnids, Daphnia magna Straus, of a single clone was maintained in a modified manure-soil medium .10 daphnids of age 8 hrs were further tested . Immobility was determined directly by placing the rack of bottles containing the animals in front of a lighted
translucent screen.
No observed effect concentration (NOEC) of test material on Daphnia magna Straus was observed to be 135 mg/l.
2.Short term toxicity of test material was evaluated on daphnia magna for 48 h.The effect concentration of test material on Daphnia magna was observed to be 374.2 mg/l.
Thus, based on the above summarised studies, 2,3-bis[(4-methylbenzoyl)oxy]succinic acid and it’s functionally similar read across substance, it can be concluded that effect concetration value is in the range of 135 - 374.2 mg/L. Thus, comparing this value with the criteria of CLP regulation, 2,3-bis[(4-methylbenzoyl)oxy]succinic acid cannot be classified for short term toxicity for aquatic invertebrate .Hence,based on the data available for the functionally similar read across, test chemical 2,3-bis[(4-methylbenzoyl)oxy]succinic acid is not likely to be toxic atleast in the dose range of 135 mg/L .
Toxicity to aquatic algae and cyanobacteria:
Data available for the predicted aquatic toxicity of target and functionally similar read across chemicals has been reviewed to determine the short term toxicity of fish of the test chemical 2,3-bis[(4-methylbenzoyl)oxy]succinic(32634 -68 -7).The studies are as mentioned below:
1.Estimated 72 hrs EC50 value of test substance2,3-bis[(4-methylbenzoyl)oxy]succinic acidon Pseudokirchneriella subcapitata was determined by three different models i.e, Battery, Leadscope and SciQSAR used within Danish QSAR database. The average EC50 value was given by the third model i.e, Battery model. Based on inhibition in growth rate of test organism Pseudokirchneriella subcapitata in a static freshwater system, the estimated 72 hrs EC50 value was predicted to be 23.548 mg/l. Thus, on the basis of EC50 value, it can be concluded that the test chemical2,3-bis[(4-methylbenzoyl)oxy]succinic acid can be considered as toxic to green algae at environmentally relevant concentrations and can be considered to be classified in aquatic acute 3 as per the CLP classification criteria.
2.The test material was used to evalute efficiency of toxicity on Scenedesmus subspicatus for 72 h. The effect concentration was observed for growth rate as well as biomass. The 72-hr ErC50 (growth rate) was calculated as 48.7 mg/L and the 72-hr EbC50 (biomass) was calculated to be 43.3 mg/L.
On the basis of above effect concentration test material can be classified as aquatic acute 3
Additional information
Short term toxicity to aquatic invertebrate:
Data available for the structurally and functionally similar read across chemicals has been reviewed to determine the short term toxicity of aquatic invertebrate of the test chemical 2,3-bis[(4-methylbenzoyl)oxy]succinic acid (32634 -68 -7).The studies are as mentioned below:
1. The test material was used to evaluate the short term toxicity test on Daphnia magna Straus .A stock of individually reared daphnids, Daphnia magna Straus, of a single clone was maintained in a modified manure-soil medium .10 daphnids of age 8 hrs were further tested . Immobility was determined directly by placing the rack of bottles containing the animals in front of a lighted
translucent screen.
No observed effect concentration (NOEC) of test material on Daphnia magna Straus was observed to be 135 mg/l.
2.Short term toxicity of test material was evaluated on daphnia magna for 48 h.The effect concentration of test material on Daphnia magna was observed to be 374.2 mg/l.
Thus, based on the above summarised studies, 2,3-bis[(4-methylbenzoyl)oxy]succinic acid and it’s functionally similar read across substance, it can be concluded that effect concetration value is in the range of 135 - 374.2 mg/L. Thus, comparing this value with the criteria of CLP regulation, 2,3-bis[(4-methylbenzoyl)oxy]succinic acid cannot be classified for short term toxicity for aquatic invertebrate .Hence,based on the data available for the functionally similar read across, test chemical 2,3-bis[(4-methylbenzoyl)oxy]succinic acid is not likely to be toxic atleast in the dose range of 135 mg/L .
Toxicity to aquatic algae and cyanobacteria:
Data available for the predicted aquatic toxicity of target and functionally similar read across chemicals has been reviewed to determine the short term toxicity of fish of the test chemical 2,3-bis[(4-methylbenzoyl)oxy]succinic(32634 -68 -7).The studies are as mentioned below:
1.Estimated 72 hrs EC50 value of test substance2,3-bis[(4-methylbenzoyl)oxy]succinic acidon Pseudokirchneriella subcapitata was determined by three different models i.e, Battery, Leadscope and SciQSAR used within Danish QSAR database. The average EC50 value was given by the third model i.e, Battery model. Based on inhibition in growth rate of test organism Pseudokirchneriella subcapitata in a static freshwater system, the estimated 72 hrs EC50 value was predicted to be 23.548 mg/l. Thus, on the basis of EC50 value, it can be concluded that the test chemical2,3-bis[(4-methylbenzoyl)oxy]succinic acid can be considered as toxic to green algae at environmentally relevant concentrations and can be considered to be classified in aquatic acute 3 as per the CLP classification criteria.
2.The test material was used to evalute efficiency of toxicity on Scenedesmus subspicatus for 72 h. The effect concentration was observed for growth rate as well as biomass. The 72-hr ErC50 (growth rate) was calculated as 48.7 mg/L and the 72-hr EbC50 (biomass) was calculated to be 43.3 mg/L.
On the basis of above effect concentration test material can be classified as aquatic acute 3
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
![ECHA](/o/diss-blank-theme/images/factsheets/A-REACH/factsheet/echa_logo.png)