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EC number: 218-301-2 | CAS number: 2110-78-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
A Daphnia sp. Acute Immobilization Test in accordance with OECD Testing Guideline 202 and GLP principles was designed to assess the potential effects of methyl 2-hydroxyisobutyrate to the freshwater cladoceran, Daphnia magna. The study was conducted as a limit test with four replicate vessels of five daphnids per test level exposed to nominal test concentrations of 0 (water control) and 100 mg methyl 2-hydroxyisobutyrate/L, over a 48-hour static exposure period. Observations were made at 24 and 48 hours (±1 hour from test initiation) for daphnid immobility (inability to swim within approximately 15 seconds after gentle agitation of the test vessel) and any changes in behavior or appearance.
The acute toxicity values for daphnid (D. magna) exposed to methyl 2-hydroxyisobutyrate over a 48-hour exposure period and based on nominal concentrations were as follows: 24- and 48-hour EC50 : >100 mg/L (limit concentration tested); 48-hour NOEC: 100 mg/L (limit concentration tested)
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
Temperatures during the exposure period ranged from 20-21°C. Dissolved oxygen levels ranged from 8.6-8.8 mg/L (97-101% air saturation). The pH ranged from 7.7-7.8 and the light intensity ranged from 354-414 lux. Test solutions were analyzed for methyl 2-hydroxyisobutyrate concentrations at test initiation and exposure termination by gas chromatography with selected ion monitoring (GC/SIM).
None of the analyses of the water control exhibited a concentration exceeding the lower limit of quantitation (LLQ) equivalent to 0.125 mg methyl 2-hydroxyisobutyrate/L. Measured concentrations of methyl 2-hydroxyisobutyrate at the limit test level ranged from 82.1 to 92.6% of the nominal concentration over the course of the exposure period. The resulting mean measured concentration was 87.4 mg methyl 2-hydroxyisobutyrate/L, equating to 87.4% of the nominal concentration. Because the mean measured concentration was within ± 20% of the nominal target concentration, results were based on the nominal (limit) concentration.
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