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Diss Factsheets
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EC number: 203-291-4 | CAS number: 105-37-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Acute Toxicity: inhalation
Administrative data
- Endpoint:
- acute toxicity: inhalation
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1988
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
Cross-reference
- Reason / purpose for cross-reference:
- reference to same study
Reference
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1988
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- documentation insufficient for assessment
- Reason / purpose for cross-reference:
- reference to same study
- Qualifier:
- no guideline available
- GLP compliance:
- not specified
- Limit test:
- yes
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Weight at study initiation: 200-300g
- Fasting period before study: yes - Route of administration:
- oral: gavage
- Vehicle:
- not specified
- Doses:
- 3 to 5 doses , maximum dose not specified, in oil
- No. of animals per sex per dose:
- 5 each sex (female/male)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- > 9.8 mL/kg bw
- Based on:
- test mat.
- Remarks on result:
- other: 8.7 g/gk bw /dose were given undiluted
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- 10.8 mL/kg bw
- Remarks on result:
- other: 9.6 g/kg bw
- Remarks:
- doses were given undiluted
- Mortality:
- death at 15 min to 1 day
- Clinical signs:
- other: lethargy and prostragation
- Gross pathology:
- Necropsy (decents) revealed red lungs, gray stomachs (with clear fluid), white to red intestines (with clear fluid) and grey to red kidneys
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Based on the result of the acute oral toxicity study in Sprague-dawley rats, the test substance has an LD50 value 8.7 to 9.6 g/kg bw.
lowest lethal dose= 8.0 mL/kg ( 7.1 g/kg bw)
The LD50 values were calculated according to the method of Thompson (1947)
female: LD50=10.8 mL/kg (8.9 to 13.1 mg/L) or 9.6 g/kg bw (7.9 to 11,7 g/kg bw)
male: LD 50 = 9.8 mgL/kg (7.2 -13.6 mL/kg) or 8.7 g/kg bw (6.4 to 12.1 g/kg bw)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 1 992
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- Animals were exposed to the vapour for defined periods of time or until death occurred, in order to define LT50 values.
- GLP compliance:
- not specified
Test material
- Reference substance name:
- Ethyl propionate
- EC Number:
- 203-291-4
- EC Name:
- Ethyl propionate
- Cas Number:
- 105-37-3
- Molecular formula:
- C5H10O2
- IUPAC Name:
- ethyl propanoate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Rats (200-300 g), using 5 per sex.
Administration / exposure
- Route of administration:
- inhalation: vapour
- Type of inhalation exposure:
- whole body
- Vehicle:
- air
- Details on inhalation exposure:
- GENERATION OF TEST ATMOSPHERE / CHAMBER DESCRIPTION
- Exposure apparatus: sealed chamber
- Exposure chamber volume: 120 litres
Sample vapour was employed in closed chamber "near saturation". No temperature is given in the report. - Analytical verification of test atmosphere concentrations:
- not specified
- Duration of exposure:
- 6 h
- Remarks on duration:
- Exposure lasted for 6 hours or until death occurred.
- Concentrations:
- Assuming a temperature of 25°C and a saturation of 90%, the vapor pressure of the substance is calculated as 55 hPa *0.9 = 49.5 hPa = 5% (v/v). With 102 g/Mol and 24.4 l/Mol a concentration of 210 mg/l is calculated.
- No. of animals per sex per dose:
- 5 per sex (female/male)
- Control animals:
- not specified
- Details on study design:
- - Duration of observation period following administration: 14 days
Results and discussion
Effect levelsopen allclose all
- Sex:
- male
- Dose descriptor:
- other: LT50
- Effect level:
- 35 other: minutes
- Based on:
- test mat.
- 95% CL:
- >= 26 - <= 47
- Exp. duration:
- 6 h
- Sex:
- female
- Dose descriptor:
- other: LT50
- Effect level:
- 32 other: minutes
- Based on:
- test mat.
- 95% CL:
- >= 23 - <= 44
- Exp. duration:
- 6 h
- Sex:
- not specified
- Dose descriptor:
- other: Only lethal exposure
- Effect level:
- 45 other: minutes
- Based on:
- test mat.
- Exp. duration:
- 6 h
- Mortality:
- Not specified.
- Clinical signs:
- other: Laboured breathing, lethargy, ataxia, lacrimation, discharge (nasal, oral) and loss of reflexes.
- Gross pathology:
- Red lungs, gas-filled stomachs and liquid-filled tracheas.
Applicant's summary and conclusion
- Interpretation of results:
- study cannot be used for classification
- Conclusions:
- Based on the results of the acute inhalation toxicity study, LT50s of 35 and 32 minutes were identified in male and female rats, respectively when exposed to near saturated vapor (estimated concentration of 210 mg/l). The available data indicate that a strong irritation of the respiratory tract occurred leading to the lethal effects found in the animals. The test substance will be classified as STOT SE 3 (H335) according to CLP.
- Executive summary:
Five male & 5 female Sprague-Dawley rats/dose level were administered the test compound as a near saturated vapour, in a sealed 120 litre chamber containing near saturated vapour for 6 hours or until death occurred. Animals were observed for 14 days. Shorter exposures were also conducted (no additional information provided) in order to calculate the LT50s by using the Thompson method. LT50s of 35 and 32 minutes were identified in male and female rats, respectively. The available data indicate that a strong irritation of the respiratory tract occurred leading to the lethal effects found in the animals. The test substance will be classified as STOT SE 3 (H335) according to CLP.
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