Registration Dossier
Registration Dossier
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EC number: 214-154-3 | CAS number: 1100-88-5
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- No data (during the year 1977)
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods with acceptable restrictions
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 977
- Report date:
- 1977
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: The Federal Hazardous substances Act (code of Federal Regulations, Title 16, Chapter II, 1976)
- Principles of method if other than guideline:
- - Principle of test:One-tenth gram of undiluted test substance was applied to the left eye of each six albino rabbits. The right eyes were untreated and served as controls.
- Parameters analysed / observed: corneal, iris and conjunctival effects were scored separately. - GLP compliance:
- no
Test material
- Reference substance name:
- Benzyltriphenylphosphonium chloride
- EC Number:
- 214-154-3
- EC Name:
- Benzyltriphenylphosphonium chloride
- Cas Number:
- 1100-88-5
- Molecular formula:
- C25H22P.Cl
- IUPAC Name:
- benzyltriphenylphosphonium chloride
- Test material form:
- solid: particulate/powder
- Details on test material:
- Argentimetric title: 100%
weight loose: 0.2%
Constituent 1
- Specific details on test material used for the study:
- SOURCE OF TEST MATERIAL
- Source and lot/batch No.of test material: Batch No. 94F-015
Test animals / tissue source
- Species:
- rabbit
- Strain:
- other: albino
- Details on test animals or tissues and environmental conditions:
- No data
Test system
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: the right eyes served as controls.
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 0.1 gram
- Duration of treatment / exposure:
- not applicable
- Observation period (in vivo):
- 72 hours
- Number of animals or in vitro replicates:
- 6 albino rabbits
- Details on study design:
- REMOVAL OF TEST SUBSTANCE
- Washing (if done): No washing
SCORING SYSTEM: similar to Draize scoring
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- cornea opacity score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 2.33
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- conjunctivae score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 3
- Reversibility:
- not specified
- Irritation parameter:
- chemosis score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Score:
- 3.66
- Max. score:
- 4
- Reversibility:
- not specified
- Irritation parameter:
- iris score
- Basis:
- animal #1
- Time point:
- 24/48/72 h
- Remarks on result:
- other: unable to score due to opacity and swelling
- Irritant / corrosive response data:
- Within 24 hours following application, the sample produced mortality in five rabbits. Irritative effects in the surviving rabbit at the 24-hour reading included moderate cornea. the effects observed were conjunctivitis, and diffuse areas of blanching in the conjunctivae and entire nictitating membrane. Irritative effects increased slightly by the 72-hour reading. Iritis could not be scored at the 72-hour reading due to severe corneal opacity.
Applicant's summary and conclusion
- Interpretation of results:
- Category 1 (irreversible effects on the eye) based on GHS criteria
- Conclusions:
- Under the conditions of this test, the test substance is considered as corrosive.
- Executive summary:
Eye irritation of benzyltriphenylphosphonium chloride was evaluated in rabbit. Six albino rabbits receives application of 0.1 g of test substance to an unwashed eye. Five to six animals died within 24 hours. In the surviving rabbit, severe swelling and opacity was seen in iris, cornea, and conjunctivae, with discharge, erythema, and blanching of the conjunctivae at 72 hours. Under the conditions of this test, the test substance is classified as corrosive (Eye Corr. 1; H318).
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