Registration Dossier
Registration Dossier
Data platform availability banner - registered substances factsheets
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 208-686-5 | CAS number: 538-23-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 01 Mar - 16 Aug 1993
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 993
- Report date:
- 1993
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- adopted in 1981
- Deviations:
- no
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Version / remarks:
- adopted in 2015
- Deviations:
- yes
- Remarks:
- No rationale for in vivo testing.
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.4 (Acute Toxicity: Dermal Irritation / Corrosion)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Remarks:
- Ministerium für Umwelt, Raumordnung und Landwirtschaft des Landes Nordrhein-Westfalen, Düsseldorf, Germany
Test material
- Reference substance name:
- Propane-1,2,3-triyl trisheptanoate
- EC Number:
- 210-647-2
- EC Name:
- Propane-1,2,3-triyl trisheptanoate
- Cas Number:
- 620-67-7
- IUPAC Name:
- propane-1,2,3-triyl triheptanoate
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- other: Small White Russian, Chbb:HM
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Dr. Karl Thomae GmbH, Biberach, Germany
- Age at study initiation: adult animals
- Weight at study initiation: 2-3 kg
- Housing: conventionally, singly in stainless steel cages
- Diet: Ssniff K 4 - Complete feed for rabbits (Ssniff, Spezial futter GmbH, Soest, Germany), ad libitum
- Water: tap water, ad libitum
- Acclimation period: at least 14 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20 ± 3
- Humidity (%): 30-70
- Air changes (per hr): 15
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- semiocclusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: untreated sites of the same animal served as control
- Amount / concentration applied:
- TEST MATERIAL
- Amount applied: 0.5 mL - Duration of treatment / exposure:
- 4 h
- Observation period:
- 14 days (2 animals)
10 days (4 animals)
Reading time points: 30-60 min, 24, 48 and 72 h, 6, 8, 10 and 14 days - Number of animals:
- 6 males
- Details on study design:
- TEST SITE
- Area of exposure: 6 cm² on the dorsal area
- Type of wrap if used: the treated skin was covered with a gauze patch and a non-irritant plaster, held in place using a semiocclusive dressing.
REMOVAL OF TEST SUBSTANCE
- Washing: the area of application was cleaned with warm water.
- Time after start of exposure: 4 h
SCORING SYSTEM: Draize scoring system
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- animal: #1, #2, #3, #4
- Remarks:
- mean after
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6-10 days
- Irritation parameter:
- erythema score
- Basis:
- animal #5
- Remarks:
- mean after
- Time point:
- 24/48/72 h
- Score:
- 3
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- erythema score
- Basis:
- animal #6
- Remarks:
- mean after
- Time point:
- 24/48/72 h
- Score:
- 2.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- edema score
- Basis:
- animal: #1, #2
- Remarks:
- mean after
- Time point:
- 24/48/72 h
- Score:
- 2
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6-14 days
- Irritation parameter:
- edema score
- Basis:
- animal #3
- Remarks:
- mean after
- Time point:
- 24/48/72 h
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 6 days
- Irritation parameter:
- edema score
- Basis:
- animal #4
- Remarks:
- mean after
- Time point:
- 24/48/72 h
- Score:
- 4
- Max. score:
- 4
- Reversibility:
- fully reversible within: 14 days
- Irritation parameter:
- edema score
- Basis:
- animal: #5, #6
- Remarks:
- mean after
- Time point:
- 24/48/72 h
- Score:
- 1.33
- Max. score:
- 4
- Reversibility:
- fully reversible within: 10 days
- Irritant / corrosive response data:
- After an exposure time of 4 h, and 30-60 min after patch removal, well-defined erythema and very slight to well-defined edema were observed in all animals. One animal showed moderate to severe erythema and severe edema with brown discolouration and dryness of the skin after 24-72 h. Sanguineous lacerations and scaling were also observed on the skin. At these time points, 4 animals showed no increase in the severity of the described signs of irritation. Moderate redness of the skin was observed in one animal after 72 h. After 72 h, this animal also showed dry skin and severe extensive subcutaneous haemorrhage. After 6 days, scaling was observed in all animals, and after 10 to 14 days, all animals were free of abnormalities.
- Other effects:
- No further local or systemic effects were reported.
Any other information on results incl. tables
Table 1. Summary of results.
Observation time |
Rabbit no. |
|||||||||||
1 |
2 |
3 |
4 |
5 |
6 |
|||||||
Erythema |
Edema |
Erythema |
Edema |
Erythema |
Edema |
Erythemy |
Edema |
Erythema |
Edema |
Erythema |
Edema |
|
0.5-1 h |
2 |
1 |
2 |
1 |
2 |
1 |
2 |
2 |
2 |
2 |
2 |
1 |
24 h |
2 |
1 |
2 |
2 |
2 |
1 |
3 |
4 |
2 |
2 |
2 |
2 |
48 h |
2 |
1 |
2 |
2 |
2 |
2* |
3 |
4 |
2* |
1* |
2 |
2 |
72 h |
2 |
1 |
2 |
2 |
2 |
1 |
3 |
4 |
2* |
1* |
3 |
2 |
6 days |
0 |
0 |
1 |
0 |
0 |
0 |
2 |
2 |
0 |
0 |
1 |
1 |
8 days |
0 |
0 |
1 |
0 |
0 |
0 |
1 |
1 |
0 |
0 |
1 |
1 |
10 days |
0 |
0 |
0 |
0 |
0 |
0 |
1 |
1 |
0 |
0 |
1 |
1 |
14 days |
nd |
nd |
nd |
nd |
nd |
nd |
0 |
0 |
nd |
nd |
0 |
0 |
Mean value |
2.00 |
1.00 |
2.00 |
2.00 |
2.00 |
1.33 |
3.00 |
4.00 |
2.00 |
1.33 |
2.33 |
2.00 |
|
||||||||||||
Observations (reading time point) |
||||||||||||
Skin discolouration |
||||||||||||
Brownish |
|
|
|
72 h |
|
|
||||||
Skin surface |
||||||||||||
Dry |
|
|
|
48-72 h |
|
72 h |
||||||
Sanguineous lacerations |
|
|
|
72 h |
|
|
||||||
Scaling |
6-8 days |
6-8 days |
6-8 days |
72 h-10 days |
6 days* |
6-8 days |
||||||
Detachment |
6-8 days |
8 days |
8 days |
6-10 days |
|
6-8 days |
||||||
Severe extensive subcutaneous haemorrhage |
|
|
|
|
|
72 h |
* local skin reaction
nd: not determined
Applicant's summary and conclusion
- Interpretation of results:
- other: CLP/EU GHS criteria not met, no classification required according to Regulation (EC) No 1272/2008.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.