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EC number: 215-709-2 | CAS number: 1344-81-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Acute toxicity: via oral route
Link to relevant study records
- Endpoint:
- acute toxicity: oral
- Remarks:
- Tessenderlo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with national standard methods
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 401 (Acute Oral Toxicity)
- GLP compliance:
- yes (incl. QA statement)
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- See it in the attachement on page 7 in the procedure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Doses:
- 100-5000 mg/kg of body weight
- No. of animals per sex per dose:
- 5
- Control animals:
- yes
- Details on study design:
- See it in the attachement.
- Statistics:
- Lithcfield, J. Jr., and Wilcoxon, F.J. Pharm. Exp. Therap. 96: 99-115 (1949)
- Key result
- Sex:
- female
- Dose descriptor:
- LD50
- Effect level:
- >= 920 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 773 - < 1 095
- Key result
- Sex:
- male
- Dose descriptor:
- LD50
- Effect level:
- >= 820 mg/kg bw
- Based on:
- test mat.
- 95% CL:
- > 773 - < 1 095
- Mortality:
- See it in the attachement on page 8 in the mortality summary table
- Clinical signs:
- other: See it in the attachement on page 7 in the results
- Gross pathology:
- See it in the attachement on page 7 in the results
- Interpretation of results:
- Category 4 based on GHS criteria
- Conclusions:
- It is classified as H302 ( acuter oral toxicity category 4)
- Executive summary:
LD 50 is 820 mg/kg bw.
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 820 mg/kg bw
- Quality of whole database:
- Klimisch 1.
Acute toxicity: via inhalation route
Link to relevant study records
- Endpoint:
- acute toxicity: inhalation
- Remarks:
- Tessenderlo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- according to guideline
- Guideline:
- other: EPA Pesticide Assessment Guidelines, Subdivision F, Hazard Evaluation, Human and Domestic Animals, November 1984
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- traditional method
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Hilltop Lab Animals, Scottdale, PA (15 males and 15 females)
- Route of administration:
- inhalation: aerosol
- Type of inhalation exposure:
- not specified
- Vehicle:
- clean air
- Mass median aerodynamic diameter (MMAD):
- >= 1.8 - <= 2.35 µm
- Details on inhalation exposure:
- See it in the attachement page 17-18
- Duration of exposure:
- ca. 4.5 h
- Concentrations:
- 2.41 mg/l , 3.78 mg/l and 5.08 mg/l
- No. of animals per sex per dose:
- 5 female and 5 male rats
- Control animals:
- no
- Statistics:
- Probit Analysis
- Key result
- Sex:
- male/female
- Dose descriptor:
- LC50
- Effect level:
- >= 3.6 mg/L air (nominal)
- Based on:
- test mat.
- 95% CL:
- >= 2.93 - <= 4.42
- Exp. duration:
- 4.5 h
- Mortality:
- At 2.41 mg/l the mortality is 30%
At 3.78 mg/l the mortality is 40%
At 5.08 mg/l the mortality is 80%
See it in the attachement on Page 30 Table 11 - Clinical signs:
- other: At 2.41 mg/l at 12 page Exposure level 2nd paragraph At 3.78 mg/l at 13. page Exposure level 2nd paragraph At 5.08 mg/l at 13. page Exposure level 2nd paragraph
- Body weight:
- Measured but not evaluated.
- Gross pathology:
- At 2.41 mg/l the 12 page Exposure level 3rd paragraph
At 3.78 mg/l the 13 page Exposure level 3rd paragraph
At 5.08 mg/l the 14 page Exposure level 3rd paragraph - Interpretation of results:
- Category 4 based on GHS criteria
- Remarks:
- H332
- Conclusions:
- LC50: 3.6 mg/l See it in the attachement on page 14 in the conclusion.
- Executive summary:
It is classified as acute tox inhalation category 4 (H332).
Reference
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LC50
- Value:
- 3 600 mg/m³ air
- Quality of whole database:
- Klimisch 1
Acute toxicity: via dermal route
Link to relevant study records
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- comparable to guideline study
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- other: EPA FIFRA guidelines Pesticide Assessment Guidelines Subsection F
- GLP compliance:
- yes (incl. QA statement)
- Test type:
- standard acute method
- Limit test:
- yes
- Species:
- rabbit
- Strain:
- New Zealand White
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- Elkhorn Rabbitry, Watsonville, CA
5 males and 5 females weighting at least 2 kg each - Type of coverage:
- occlusive
- Vehicle:
- not specified
- Details on dermal exposure:
- See it in the attachement page 5. procedure 3.4.5. paragraph.
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg/kg
- No. of animals per sex per dose:
- 5 female and 5 male rabbits
- Control animals:
- no
- Key result
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 000 mg/kg bw
- Based on:
- test mat.
- Mortality:
- All animals survived the test period.
- Clinical signs:
- other: Several local irritation including necrosis was observed on all of the animals on the skin of the test sites. Wounds were beaginnig to heal by day 10. No systemic toxic signs were observed during the test.
- Gross pathology:
- No test compound related abnormalities were observed.
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- At a dermal dose of 2000 mg/kg bw, this test compund produces no mortalities among male and female NZW rabbits.
- Executive summary:
At a dermal dose of 2000 mg/kg bw, this test compund produces no mortalities among male and female NZW rabbits.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Dose descriptor:
- LD50
- Value:
- 2 001 mg/kg bw
- Quality of whole database:
- At a dermal dose of 2000 mg/kg bw, this test compund produces no mortalities among male and female NZW rabbits.
Additional information
Justification for classification or non-classification
It is classified as H302 and H332 ( acute tox category 4)
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