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EC number: 219-440-1 | CAS number: 2437-25-4
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Water solubility
Administrative data
- Endpoint:
- water solubility
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- Aug-Sep 2007
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Recent study according to guidelines and GLP.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 007
- Report date:
- 2007
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 105 (Water Solubility)
- Deviations:
- no
- GLP compliance:
- yes (incl. QA statement)
- Type of method:
- column elution method
Test material
- Reference substance name:
- Dodecanenitrile
- EC Number:
- 219-440-1
- EC Name:
- Dodecanenitrile
- Cas Number:
- 2437-25-4
- Molecular formula:
- C12H23N
- IUPAC Name:
- dodecanenitrile
- Details on test material:
- Certificate included in report:
Sigma-Aldrich
Product Name Dodecanenitrile, 99%
Product Number U1605
Product Brand Aldrich
CAS Number 2437-25-4
Molecular Formula CH3(CH2)10CN
Molecular Weight 181.32
TEST LOT S14287 RESULTS
QC Acceptance date 22-NOV-2002
APPEARANCE - Clarity CLEAR
APPMRANCE - Colour COLOURLESS
APPEARANCE -State LIQUlD
FT-IR SPECTROSCOPY - FTIR SPECTRUM: CONFORMS TO REFERENCE
FT-IR SPECTROSCOPY - REFERENCE 2(1), 1425C
REFRACTIVE INDEX 1.4363
GAS CHROMATOGRAPHY - PURITY 99.40%
Constituent 1
Results and discussion
Water solubility
- Water solubility:
- 0.93 mg/L
- Temp.:
- 21 °C
- pH:
- 6.14 - 7.63
- Remarks on result:
- other: +/- 0.25 mg/L
- Details on results:
- The water solubility of Dodecanenitrile at 21 °C was determined to be 0.93 mg/L ± 0.25 mg/L.
Any other information on results incl. tables
Results of the water solubility of Dodecanenitrile
Experiment No. | Flow rate (mL/h) |
Sample No. | Concentration analyzed (µg/mL) |
Water solubility calculated (mg/L) |
pH | ||
1 | 31 | 1 | 0,909 | 0,93 SD = ± 0,25 |
6,65 | ||
2 | 1,230 | 6,31 | |||||
3 | 1,456 | 6,16 | |||||
4 | 1,126 | 6,55 | |||||
5 | 1,044 | 6,61 | |||||
6 | 0,925 | 6,47 | |||||
2 | 16 | 7 | 0,780 | 7,63 | |||
8 | 0,977 | 6,14 | |||||
9 | 0,752 | 6,36 | |||||
10 | 0,585 | 6,19 | |||||
11 | 0,663 | 6,74 | |||||
12 | 0,714 | 6,34 |
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): slightly soluble (0.1-100 mg/L)
The water solubility of Dodecanenitrile at 21 °C was determined to be 0.93 mg/L ± 0.25 mg/L. - Executive summary:
The determination of the water solubility of Dodecanenitrile was performed according to the EEC Directive 92/69, A6 "Water Solubility" (1992) and the OECD guideline No105, "Water Solubility" (adopted July 27, 1995), using the column elution method.
During the preliminary test the water solubility of Dodecanenitrile at room temperature was estimated by a simplified flask method to be lower than the smallest calibration point of 0.8373 µg/mLTherefore, the column elution method was used for the performance of the main test.
During the main test six samples have been analyzed in the first run (0.52 mL/min) and six samples during the second run (0.26 mL/min), each with a sampling interval of one hourTotal elution time was 192 hoursThe sample measurement was performed by GC.
The measured results differ by less than 30%Therefore, the study is considered to be valid.
Concurrent with the sample analysis, recoveries of spiked water samples (25.4 µg/ml and 5.08 µg/ml) were tested. The recoveries of the spiked samples were 95% and 892% respectively. These results show the suitability of the work-up procedure used for the aqueous test sample solutions.
The r2 fit for the calibration curve was 0.9997 (optimum 1.0000)This reflects the linearity of the GC-system within the calibration range of 0.3999 µg/mL to 7.9975 µg/mL of the test item.
In conclusion, the water solubility of Dodecanenitrile at 21 °C was determined to be 0.93 mg/L (± 0.25 mg/L) using the column elution method.
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