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Diss Factsheets
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EC number: 944-548-7 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
No studies on the toxicity of insulin Aspart Ethyl Ester towards algae, invertebrates and fish were available.
The aquatic toxicity of Insulin Aspart Ethyl Ester is assumed to be similar to the source substance (S4) because of the high degree of structural similarity:
• Insulin Aspart Ethyl Ester and the source substance belong to the same chemical categories: human insulins, polypeptides and proteins
• Insulin Aspart Ethyl Ester and the source substance are composed of polypeptide containing amino acids.
Insulin Aspart Ethyl Ester is predicted to have a toxicity to algae with EC10 and EC50 of > 300 mg/L (geometric mean concentration) based on the results from the study with Insulin Aspart Precursor. No effects towards algae was observed during the study with Insulin Aspart Precursor (S4) and EC10 and EC50 are therefore reported as > 300 mg/L (> 258 geometric mean concentration).
Insulin Aspart Ethyl Ester is predicted to have a toxicity to invertebrates with EC10 and EC50 of > 300 mg/L (geometric mean concentration) based on the results from the study with Insulin Aspart Precursor. No effects were observed towards invertebrates during the study with Insulin Aspart Precursor (S4) and EC10 and EC50 are therefore reported as > 300 mg/L (> 254.8 mg/L geometric mean concentration).
Insulin Aspart Ethyl Ester is predicted to have a toxicity to fish with LC50 of > 50,1 mg/L (geometric mean concentration) based on the results from the study with Insulin Aspart Precursor. No mortality to fish was observed during the study with Insulin Aspart Precursor (S4) and LC50 is therefore reported as > 50,1 mg/L (geometric mean concentration).
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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