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Diss Factsheets
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EC number: 806-984-5 | CAS number: 1392411-89-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Link to relevant study record(s)
Description of key information
No studies on the toxicokinetic properties of the test substance were available. However, according to the REACH guidance document R7.C (June 2017), information on absorption, distribution, metabolism and excretion may be deduced from the physicochemical properties. Based on the phys-chem properties and the available toxicological data, the substance is expected to be partially absorbed by the oral route but less likely by the dermal route, with an overall low bioaccumulation potential.
Key value for chemical safety assessment
- Bioaccumulation potential:
- low bioaccumulation potential
- Absorption rate - oral (%):
- 50
- Absorption rate - dermal (%):
- 50
- Absorption rate - inhalation (%):
- 100
Additional information
There are no published data which could be identified on the toxicokinetics of the substance. However, as per REACH guidance document R7. C (June 2017), information on absorption, distribution, metabolism and excretion may be deduced from the physico-chemical properties including:
- Water solubility
- Partition coefficient
- Vapour pressure
- Molecular weight
The substance is a UVCB, with majority of the constituents having a molecular weight >500. It is a liquid with a tested water solubility of 183.5 mg/L. Volatility was determined to be very low (4.44 E-6 Pa at 20°C) and has a limited lipophilic character (log Kow of the major components between 1.323 and 3.617). Taking into account the upper limit of log Kow (3.6) and the water solubility (183.5 mg/L), accumulation of the substance is considered to be unlikely.
Oral and gastrointestinal (GI) absorption: Given the water solubility and partition coefficient range of the substance, it is likely to be partially soluble in GI fluid. However, based on the high molecular weight of majority of the constituents, it can then be expected to be partially absorbed through the GI system. Reversible, adaptive increase in liver weights was observed at the high dose animals in the repeated dose toxicity study. This confirms the oral absorption of the substance. However, in absence of actual data, the default value of 50% has been considered for the oral absorption.
Inhalation absorption: Given the log Kow range of the major constituents and the indication for oral absorption, possible systemic uptake of the substance after inhalation exposure could be expected, although this would occur only when aerosol or vapour is created under particular conditions (e.g. spraying, elevated temperature/pressure). Therefore, a worst-case value of 100% has been considered for the inhalation absorption.
Dermal absorption: Dermal absorption of the substance is expected to be slow due to binding to skin of the acrylate group. According to REACH guidance document R7.C (June 2017), dermal absorption is maximal for substances with molecular weights below 500 and log Kow values ranging between 1 and 2. The majority of the constituents of the substance have average molecular weights of >500 g/mol and log Kows between 1.3 and 3.6. This suggests that the substance may not penetrate very easily through skin. However, the substance is a skin irritant cat. 2 and a skin sensitizer cat. 1B which suggests dermal absorption to some extent. Predictions for dermal penetration from the DERMWIN software of EPISUITE 4.1 indicates that the low molecular weight constituents (which represents approx 30% of the total substance) have low dermal absorption. Therefore, owing to the observed local dermal effects a conservative estimate of 50% has been considered for human dermal absorption.
Bioaccumulation potential: Based on the physico-chemical information (log Kow, structure not containing ionisable elements and water solubility), it is concluded that the potential for bioaccumulation is low.
Metabolism: No specific information could be found on metabolism, but evidence from other types of acrylates suggests that hydrolysis of the ester bond is likely to occur, producing acrylic acid and the corresponding alcohol, which are subsequently metabolised through usual metabolic routes. This hydrolysis is mediated by the ubiquitous tissues and circulating carboxylesterases.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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