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EC number: 248-595-8 | CAS number: 27668-52-6
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
Description of key information
Short term toxicity to aquatic invertebrates was performed in Daphnia magna for 48 hrs in static condition. EC50 value and No-observable-effect-level (NOEL) for Short term toxicity to aquatic invertebrates based on intoxication effect for 48hrs was determined to be 0.72mg/l and 0.3 mg/l for Daphnia magna species in fresh water and static condition.
Based on the value the Dimethyloctadecyl [3-(trimethoxysilyl) propyl] ammonium chloride (27668-52-6) was considered to be hazardous to aquatic invertebrates and can be classified in aquatic chronic 1 and acute 1 category.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 0.72 mg/L
Additional information
Various studies for the Dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride (27668-52-6)) and read across were reviewed to summarize the following information:
Short term toxicity to aquatic invertebrates was performed in Daphnia magna for 48 hrs in static condition.EC 50 value and No-observable-effect-level (NOEL) for Short term toxicity to aquatic invertebrates based on intoxication effect for 48hrs was determined to be 0.72mg/l and 0.3 mg/l for Daphnia magna species in fresh water and static condition.
Based on the value the Dimethyloctadecyl [3-(trimethoxysilyl) propyl] ammonium chloride (27668-52-6) was considered to be hazardous to aquatic invertebrates and can be classified in aquatic chronic 1 and acute 1 category.
48 hrs aquatic toxicity studies(EPI suite, ECOSAR version 1.1, 2016) were conducted to assess toxic effects of theDimethyloctadecyl [3-(trimethoxysilyl) propyl] ammonium chloride (27668-52-6))and the results were predicted. The study was based on the effects of the test compound on the Daphnia magna in a static fresh water system. The predicted data suggests the lethal concentration (LC50) forDimethyloctadecyl [3-(trimethoxysilyl) propyl] ammonium chloride (27668-52-6))wasestimated to be 0.760 mg/l.As theDimethyloctadecyl [3-(trimethoxysilyl) propyl] ammonium chloride (27668-52-6))wasconsidered being hazardous to aquatic invertebrates can be considered to be classified in aquatic chronic 1 and acute 1category as per the CLP regulations.
A study on read across Benzododecinium chloride (139-07-1) for short term toxicity to aquatic invertebrates was performed in Daphnia magna (j-check, NITE (2001), Toxicity data survey work in 2001 fiscal year, Acute Immobilization Test of Benzyl (dodecyl)dimethylammonium chloride to Daphnia magna) for 48 hrs according to the OECD guideline 202. Nominal concentrations of 0, 0.010, 0.018, 0.032, 0.056, 0.10 mg/L were used. Test conditions as semi static test type for 48 hrs were used. 100ml of test solution with 5 daphnids per vessels and 4 replicates were used. After the experiment, the EC 50 value for Benzododecinium chloride (139-07-1) of short term toxicity to aquatic invertebrates was determined to be 0.032 mg/l on the basis of mobility.
Another study on read across chemical Hexadecyltrimethylammonium bromide (57-09-0), which has 60-70% structural similarity, for a short term toxicity to aquatic invertebrates test (J-check, Ministry of Health, Labour and Welfare, Ministry of Economy, Trade and Industry, and Ministry of the Environment)2005) was performed in Daphnia magna for 48 hrs according to the OECD guideline 202. Nominal concentrations of control, 0.0100, 0.0180, 0.0320, 0.0560, 0.100 mg/L, geometric ratio: 1.8 mg/L were used. Test conditions as semi static test type for 48 hrs were used for test. 100ml of test solution with 5 daphnids per vessels and 4 replicates were used. After the experiment, the EC 50 value for Hexadecyltrimethylammonium bromide (57-09-0) of short term toxicity to aquatic invertebrates was determined to be 0.0157 mg/l on the basis of mobility.
Based on the value of Dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride (27668-52-6) and read across chemicals Benzododecinium chloride (139-07-1) which has 50-60% structural similarity and Hexadecyltrimethylammonium bromide (57-09-0) which has 60-70% structural similarity, it was concluded that Dimethyloctadecyl[3-(trimethoxysilyl)propyl]ammonium chloride (27668-52-6) was considered to be hazardous to aquatic invertebrates and can be classified in aquatic chronic 1 and acute 1 category.
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