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EC number: 209-939-2 | CAS number: 598-55-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- From December 27, 1980 to January 31, 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Study is well documented and meets generally accepted scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
Test guideline
- Qualifier:
- no guideline followed
Test material
- Reference substance name:
- Methyl carbamate
- EC Number:
- 209-939-2
- EC Name:
- Methyl carbamate
- Cas Number:
- 598-55-0
- Molecular formula:
- C2H5NO2
- IUPAC Name:
- methyl carbamate
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Charles River, Portage, Michigan
- Date of birth of test animals: November 21, 1979 to November 28, 1979
- Date of arrival: December 27, 1979
- Housing: Polycarbonate cages with snow filtration filter sheets and placed in stainless steel racks
- Water: City, untreated; ad libitum.
- Quarantine Period: December 27, 1979 to January 14, 1980
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 12.8- 26.7°C (55-80°F)
- Humidity (%): 55-80%
- Air: Air filtered through a Flanders air filter, AC45L
IN-LIFE DATES: From January 15, 1980 to January 31, 1980
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- water
- Details on oral exposure:
- PREPARATION OF DOSING SOLUTIONS:
The appropriate weight of test substance for each dose was weighed out in a 100 mL volumetric flask. Water was added to the 100 mL mark, the flask was stoppered and the contents were shaken until the solution was thoroughly mixed. Test substance doses were prepared in sufficient quantities for one week's dosing. Doses were prepared on the Friday prior to expected usage. All test substance doses were stored at room temperature and used within 8 d of initial preparation. - Duration of treatment / exposure:
- 17 d
- Frequency of treatment:
- Once daily (doses were not given on weekends) and at least two consecutive doses administered prior to the day of the scheduled terminal sacrifice.
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 250, 500, 1,000, 2,000 and 4,000 mg/kg bw/day
Basis:
actual ingested
- Control animals:
- yes
- Details on study design:
- Method of dosing: Stainless steel animal feeding tube (gavage needle with ball tip - 3 inch, 18 gauge) in 2.5 mL glass syringes (needles: Popper and Sons, Inc., New Hyde, N.Y.; syringes: B-D, Inc.)
Volume: 5 mL/kg bw
Length of compound administration: 12 individual doses for each surviving animal given on consecutive week days (doses were not given on weekends)
Method of sacrifice: CO2 asphyxiation
Examinations
- Observations and examinations performed and frequency:
- Observation Period: Twice daily observations
DETAILED CLINICAL OBSERVATIONS: Yes
BODY WEIGHT: Yes
- Time schedule for examinations: At start and termination of study - Sacrifice and pathology:
- GROSS PATHOLOGY: Yes
HISTOPATHOLOGY: Yes
Results and discussion
Results of examinations
- Clinical signs:
- effects observed, treatment-related
- Mortality:
- mortality observed, treatment-related
- Body weight and weight changes:
- effects observed, treatment-related
- Histopathological findings: non-neoplastic:
- effects observed, treatment-related
- Details on results:
- CLINICAL SIGNS AND MORTALITY
The two highest doses (2,000 and 4,000 mg/kg bw/day) were lethal to all male and female rats. 3 male rats died in the 1,000 mg/kg bw/day dosage group. Clinical signs of toxicity were observed in male and female rats receiving 1,000 mg/kg bw/day or higher doses.
BODY WEIGHT AND WEIGHT GAIN
Relative weight gains were suppressed in all dosage groups.
GROSS PATHOLOGY
Gross observations at necropsy indicate hemorrhaging in the GI tract, subcutaneous vascular bed and brain in some rats receiving 1,000 mg/kg bw/day or higher doses. Some female rats receiving 250, 500 and 1,000 mg/kg bw/day demonstrated reproductive tract lesions.
HISTOPATHOLOGY
No toxicity related microscopic lesions were observed in rats receiving 500 mg/kg bw/day.
Effect levels
- Dose descriptor:
- NOAEL
- Effect level:
- 500 mg/kg bw/day (actual dose received)
- Based on:
- test mat.
- Sex:
- male/female
Target system / organ toxicity
- Critical effects observed:
- not specified
Applicant's summary and conclusion
- Conclusions:
- The no observed adverse effect level (NOAEL) for the test substance can be established at 500 mg/kg bw/day.
- Executive summary:
A study was conducted to assess the toxicity of the test substance following repeated administration. On basis of acute dose toxicity test, test substance was given to males and females rats at dose levels of 0, 250, 500, 1,000, 2,000 and 4,000 mg/kg bw/day for 17 d on consecutive week days (doses were not given on weekends). All dose levels were prepared with water as vehicle and in sufficient quantities for one week's dosing. All dosing solutions were stored at room temperature and used within 8 d of preparation. Parameters measured during the study included mortality, observation of clinical signs, body weight and gross pathology evaluation. Animals were sacrificed by CO2 asphyxiation and gross necropsy was performed for all surviving animals. All male and female rats in the two highest doses (2,000 and 4,000 mg/kg bw/day) died by Day 4. Three male rats died in the 1,000 mg/kg bw/day dose level. There was reduction in relative weight gains at all dose levels. Clinical signs of toxicity were observed in male and female rats dosed with 1,000 mg/kg/day or higher doses. Gross observations at necropsy revealed hemorrhaging in the GI tract, subcutaneous vascular bed and brain in some rats receiving 1,000 mg/kg bw/day or higher doses. Reproductive tract lesions were also observed in some female rats receiving 250, 500 and 1,000 mg/kg bw/day dose. No toxicity related microscopic lesions were observed in rats receiving 500 mg/kg bw/day. Under the conditions of this study, the no observed adverse effect level (NOAEL) for the test substance can be established at 500 mg/kg bw/day (Dinowitz M, 1980).
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