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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
Diss Factsheets
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EC number: 931-242-3 | CAS number: -
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well-documented publication which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 982
- Report date:
- 1982
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
- Deviations:
- yes
- Remarks:
- test substance applied under occlusive conditions, observation period to short for assessment of full reversibility
- GLP compliance:
- no
Test material
- Reference substance name:
- Retinyl acetate
- EC Number:
- 204-844-2
- EC Name:
- Retinyl acetate
- Cas Number:
- 127-47-9
- Molecular formula:
- C22H32O2
- IUPAC Name:
- [(2E,4E,6E,8E)-3,7-dimethyl-9-(2,6,6-trimethylcyclohexen-1-yl)nona-2,4,6,8-tetraenyl] acetate
- Details on test material:
- Vitamin A acetate (CAS No. 127-47-9), purity 2.8 mio IU/g (ca. 860 mg Vitamin A acetate/g or 86%) in arachis oil.
Two specifications tested, i.e. Vitamin-A-Acetat and Vitamin-A-Acetat (external product). No furhter data available
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- Vienna White
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Gaukler, Offenbach (Germany)
- Weight at study initiation: individual animals: 3.61, 3.23 and 2.92 kg for the males and 2.91, 2.95 and 3.14 kg for females.
- Housing: single
- Diet (e.g. ad libitum): approx. 130 g per animal daily
- Water (e.g. ad libitum): approx. 250 ml per animal daily
- Acclimation period: approx. 8 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20-24
- Humidity (%): 30-70
- Photoperiod (hrs dark / hrs light): 12/12
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- other: clipping at least 15 hours before test substance administration
- Vehicle:
- unchanged (no vehicle)
- Controls:
- other: Untreated skin sites of the same animals served as control.
- Amount / concentration applied:
- undiluted
- Duration of treatment / exposure:
- 4 hour(s)
- Observation period:
- The skin was scored at 30-60 minutes after removal of the test patches and at 24, 48, 72 hours, and 8 days after beginning of application.
- Number of animals:
- 6 (3 male, 3 female)
- Details on study design:
- A test patch sized ca. 2.5 cm x 2.5 cm was soaked with approximately 0.5 ml of the test article and applied to the shaved dorsal skin of each animal under occlusive conditions for 4 hours. At the end of the exposure period, the skin was washed with Lutrol and Lutrol/water (1:1).
Scoring according to OECD guideline.
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- erythema score
- Basis:
- mean
- Remarks:
- animal 1-6
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 2.3
- Max. score:
- 4
- Reversibility:
- not fully reversible within: 8 days
- Remarks on result:
- other: in 5/6 animals
- Irritation parameter:
- edema score
- Basis:
- mean
- Remarks:
- animal 1-6
- Time point:
- other: 24, 48 and 72 hours
- Score:
- 1
- Max. score:
- 4
- Reversibility:
- fully reversible within: 8 days
Any other information on results incl. tables
The result for Vitamin A acetate in arachis oil is presented
in this entry. Comparable findings were observed for Vitamin A acetate (external product) (data not shown).
Table: Individual Draize scores and findings at intact skin sites
animal eryth. edema symptoms
no
---------------------------------
4-hour reading
1 1 0 R:U
2 1 0 R:U
3 1 0 R:U
4 1 0 R:U
5 1 0 R:U
6 1 0 R:U
- - - - - - - - - - - - - - - - -
24-hour reading
1 2 1 R:U/OE:U
2 2 1 R:U/OE:U
3 2 1 R:U/OE:U
4 2 1 R:U/OE:U
5 2 1 R:U/OE:U
6 2 1 R:U/OE:U
- - - - - - - - - - - - - - - - -
48-hour reading
1 2 1 R:U/OE:U
2 2 1 R:U/OE:U
3 2 1 R:U/OE:U
4 3 1 R:U/OE:U
5 2 1 R:U/OE:U
6 3 1 R:U/OE:U/HE
- - - - - - - - - - - - - - - - -
72-hour reading
1 2 1 R:U/OE:U/HE
2 2 1 R:U/OE:U
3 2 1 R:U/OE:U
4 3 1 R:U/OE/U/HE
5 3 1 R:U/OE:U
6 3 1 R:U/OE:U/HE
- - - - - - - - - - - - - - - - -
8-day reading
1 1 0 S
2 1 0 S
3 1 0 S
4 0 0 S
5 1 0 S
6 1 0 S
---------------------------------
Abbreviations used for symptoms:
R:U = erythema exceeding the application area
OE:U = edema exceeding the application area
HE = hemorrhagic
S = desquamation
Mean scores 24 - 72 h reading
Animal Erythema Edema
-----------------------------
1 2.0 1.0
2 2.0 1.0
3 2.0 1.0
4 2.7 1.0
5 2.3 1.0
6 2.7 1.0
- - - - - - - - - - - - - - -
Mean scores 24 - 72 h reading
Animal Erythema Edema
-----------------------------
1-6 2.3 1.0
Applicant's summary and conclusion
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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