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EC number: 235-118-3 | CAS number: 12070-06-3
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Basic toxicokinetics
Administrative data
- Endpoint:
- basic toxicokinetics in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2013-12-05 to 2014-02-21
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Meets generally accepted scientific standards, well documented and acceptable for assessment.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 014
- Report date:
- 2014
Materials and methods
- Objective of study:
- bioaccessibility (or bioavailability)
Test guideline
- Qualifier:
- no guideline available
- Deviations:
- not applicable
- Principles of method if other than guideline:
- This report measured bioaccessibility of tantalum carbide in body fluid simulants as a surrogate for bioavailability.
- GLP compliance:
- no
Test material
- Reference substance name:
- Tantalum carbide
- EC Number:
- 235-118-3
- EC Name:
- Tantalum carbide
- Cas Number:
- 12070-06-3
- Molecular formula:
- CTa
- IUPAC Name:
- methyltantalum
- Test material form:
- solid: particulate/powder
- Remarks:
- migrated information: powder
- Details on test material:
- - Name of test material (as cited in study report): Tantalum Carbide
- Analytical purity: 93.8% Tantalum
Constituent 1
- Radiolabelling:
- no
Test animals
- Species:
- other: not applicable
- Strain:
- other: not applicable
- Details on test animals or test system and environmental conditions:
- not applicable
Administration / exposure
- Route of administration:
- other: in vitro study
- Vehicle:
- other: in vitro study
- Details on exposure:
- not applicable
- Duration and frequency of treatment / exposure:
- not applicable
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0.1 g of test substance in 50 mL of simulated fluid
- No. of animals per sex per dose / concentration:
- not applicable
- Control animals:
- other: not applicable
- Positive control reference chemical:
- not applicable
- Details on study design:
- Tantalum carbide was extracted in leaching fluids for different time periods: 2 hrs and 24 hrs in simulated gastric and lysosomal fluid, 24 hrs in simulated interstitial fluid and 12 hrs in artificial perspiration. The extractions were performed using 0.1 gram of sample in 50 ml of simulated fluid. A shaker water bath at a temperature of 37± 2°C was used. All extractions were performed in duplicate. The extracts were analyzed for soluble Tantalum using EPA Method #200.8 (ICP/MS). Results were reported as µg Ta/g sample, % Ta/g sample and as % of total Ta released/Tantalum content.
- Details on dosing and sampling:
- not applicable
- Statistics:
- not applicable
Results and discussion
- Preliminary studies:
- not applicable
Toxicokinetic / pharmacokinetic studies
- Details on absorption:
- not applicable
- Details on distribution in tissues:
- not applicable
- Details on excretion:
- not applicable
Metabolite characterisation studies
- Metabolites identified:
- not measured
- Details on metabolites:
- not applicable
Bioaccessibility (or Bioavailability)
- Bioaccessibility (or Bioavailability) testing results:
- see tables in section " any other information on results incl. tables"
Any other information on results incl. tables
Table 1: Soluble Tantalum in Gastric fluid
Extraction time in h |
Weight used |
µg Tantalum /g Sample |
% Tantalum release/ Tantalum content |
2 hours |
0.1034 |
<25.0 |
-- |
(dup) |
0.1010 |
<25.0 |
-- |
24 hours |
0.1059 |
<25.0 |
-- |
(dup) |
0.1007 |
<25.0 |
-- |
Table 2: Soluble Tantalum in Interstitial fluid
Extraction time in h |
Weight used |
µg Tantalum /g Sample |
% Tantalum release/ Tantalum content |
2 hours |
0.1000 |
<25.0 |
-- |
(dup) |
0.1008 |
<25.0 |
-- |
24 hours |
0.1043 |
<25.0 |
-- |
(dup) |
0.1016 |
<25.0 |
-- |
Table 3: Soluble Tantalum in Lysosomal fluid
Extraction time in h |
Weight used |
µg Tantalum /g Sample |
% Tantalum release/ Tantalum content |
2 hours |
0.1036 |
<25.0 |
-- |
(dup) |
0.1024 |
<25.0 |
-- |
24 hours |
0.1042 |
43.0 |
0.005 |
(dup) |
0.1048 |
33.0 |
0.004 |
Table 4: Soluble Tantalum in Artificial Perspiration
Extraction time in h |
Weight used |
µg Tantalum /g Sample |
% Tantalum release/ Tantalum content |
2 hours |
0.1010 |
<25.0 |
-- |
(dup) |
0.1019 |
<25.0 |
-- |
24 hours |
0.1032 |
<25.0 |
-- |
(dup) |
0.1014 |
<25.0 |
-- |
Table 5: Soluble Tantalum in PBS
Extraction time in h |
Weight used |
µg Tantalum /g Sample |
% Tantalum release/ Tantalum content |
2 hours |
0.1037 |
<25.0 |
-- |
(dup) |
0.1051 |
<25.0 |
-- |
24 hours |
0.1008 |
25.0 |
0.003 |
(dup) |
0.1040 |
34.0 |
0.004 |
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): low bioaccumulation potential based on study results
The release of tantalum ions from tantalum carbide is very low in artificial body fluids. For simulated gastric fluid, simulated interstitial fluid and arteficial perspiration no release of tantalum ions was observed as the results were below the detection limit of the method.
Only in simulated lysosomal fluid 0.005% tantalum ions were released within 24 hours from tantalum carbide. - Executive summary:
This report measured bioaccessibility of tantalum carbide as a surrogate for bioavailability. Thus, the soluble tantalum was measured by using EPA Method #200.8 (ICP/MS) after incubation of tantalum carbide in different simulated body fluids (simulated gastric fluid, simulated interstitial fluid, simulated lysosomal fluid, and artificial perspiration). Results were reported as µg Ta/g sample, % Ta release/Ta content.
Overview of Tantalum released in the different simulated body fluids:
Medium
t in h
% Ta-release
Simulated gastric fluid
2
BDL
24
BDL
Simulated interstitial fluid
2
BDL
24
BDL
Simulated lysosomal fluid
2
BDL
24
0,005%
Artificial perspiration
2
BDL
24
BDL
PBS
2
BDL
24
0,004%
BDL – Below method detection limit
In summary, release of tantalum ions from tantalum carbide is very low. The actually measured release of tantalum in lysosomal fluid is in the same magnitude as the reference fluid (PBS). Based on the results, the bioavailability of tantalum carbide is expected to be very low for all routes of administration.
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